N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-(carbobenzoxyamino)propylamide

Base Information

Chemical Name:N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-(carbobenzoxyamino)propylamide
CAS No.:86787-33-9
Molecular Formula:C₃₈H₄₈N₄O₈
Molecular Weight:688.821
Hs Code.:

Synonyms:N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-(carbobenzoxyamino)propylamide

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Chemical Property of N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-(carbobenzoxyamino)propylamide

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Technology Process of N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-(carbobenzoxyamino)propylamide

There total 7 articles about N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-(carbobenzoxyamino)propylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 17400-34-9
(3-aminopropyl)carbamic acid benzyl ester hydrochloride

: 86778-74-7
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine

: 86787-33-9
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-(carbobenzoxyamino)propylamide

Guidance literature:: With N-Ethylmaleimide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; at 25 ℃; for 48h; pH 7.0-7.5;
DOI:10.1021/jm00369a017

Reference yield:

: 7021-11-6
4-(4-hydroxyphenyl)butanoic acid

: 86787-33-9
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-(carbobenzoxyamino)propylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / HOBt, NEM, DCC / tetrahydrofuran; dimethylformamide / 17 h / 25 °C / pH 7.0-7.5

2: 100 percent / H₂ / 10percent Pd/C (wet with H₂O) / ethanol / 3 h / 3102.9 Torr

3: 100 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / 25 °C / pH 7.0-7.5

4: 66 percent / 2.5 N NaOH / methanol / 25 °C

5: 63 percent / HOBt, NEM, DCC / tetrahydrofuran; dimethylformamide / 48 h / 25 °C / pH 7.0-7.5

With N-Ethylmaleimide; sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on carbon; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00369a017

Reference yield:

: 22320-10-1
methyl 4-(4-hydroxyphenyl)butanoate

: 86787-33-9
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-(carbobenzoxyamino)propylamide

Guidance literature:: Multi-step reaction with 6 steps

1: 48percent HBr / acetic acid / Heating

2: 83 percent / HOBt, NEM, DCC / tetrahydrofuran; dimethylformamide / 17 h / 25 °C / pH 7.0-7.5

3: 100 percent / H₂ / 10percent Pd/C (wet with H₂O) / ethanol / 3 h / 3102.9 Torr

4: 100 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / 25 °C / pH 7.0-7.5

5: 66 percent / 2.5 N NaOH / methanol / 25 °C

6: 63 percent / HOBt, NEM, DCC / tetrahydrofuran; dimethylformamide / 48 h / 25 °C / pH 7.0-7.5

With N-Ethylmaleimide; sodium hydroxide; hydrogen bromide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on carbon; In tetrahydrofuran; methanol; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00369a017