2-[Hydroxy-(2-{3-[2-(1-hydroxy-2-methoxycarbonyl-allyl)-phenoxy]-propoxy}-phenyl)-methyl]-acrylic acid methyl ester

Base Information

• Chemical Name: 2-[Hydroxy-(2-{3-[2-(1-hydroxy-2-methoxycarbonyl-allyl)-phenoxy]-propoxy}-phenyl)-methyl]-acrylic acid methyl ester
• CAS No.: 158629-86-8
• Molecular Formula: C₂₅H₂₈O₈
• Molecular Weight: 456.493
• Mol file: 158629-86-8.mol

Synonyms:2-[Hydroxy-(2-{3-[2-(1-hydroxy-2-methoxycarbonyl-allyl)-phenoxy]-propoxy}-phenyl)-methyl]-acrylic acid methyl ester

Chemical Property of 2-[Hydroxy-(2-{3-[2-(1-hydroxy-2-methoxycarbonyl-allyl)-phenoxy]-propoxy}-phenyl)-methyl]-acrylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[Hydroxy-(2-{3-[2-(1-hydroxy-2-methoxycarbonyl-allyl)-phenoxy]-propoxy}-phenyl)-methyl]-acrylic acid methyl ester

There total 1 articles about 2-[Hydroxy-(2-{3-[2-(1-hydroxy-2-methoxycarbonyl-allyl)-phenoxy]-propoxy}-phenyl)-methyl]-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-[3-(2-formylphenoxy)propoxy]benzaldehyde (17954-12-0) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 2-[Hydroxy-(2-{3-[2-(1-hydroxy-2-methoxycarbonyl-allyl)-phenoxy]-propoxy}-phenyl)-methyl]-acrylic acid methyl ester (158629-86-8)

Guidance literature:

With 3-quinuclidinol; for 504h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85265-0

Reference yield: 90.0%

acetyl chloride (75-36-5) + 2-[Hydroxy-(2-{3-[2-(1-hydroxy-2-methoxycarbonyl-allyl)-phenoxy]-propoxy}-phenyl)-methyl]-acrylic acid methyl ester (158629-86-8) → 2-[Acetoxy-(2-{3-[2-(1-acetoxy-2-methoxycarbonyl-allyl)-phenoxy]-propoxy}-phenyl)-methyl]-acrylic acid methyl ester (158629-87-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; diethyl ether; for 5h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85265-0

Reference yield:

2-[Hydroxy-(2-{3-[2-(1-hydroxy-2-methoxycarbonyl-allyl)-phenoxy]-propoxy}-phenyl)-methyl]-acrylic acid methyl ester (158629-86-8) → dimethyl 8,9,18,19-tetrahydro-8-(2'-methoxycarbonyl-3'-phenylprop-2'enyl)-7H,17H dibenzo <14,20,8> dioxaazacyclohexadecine-6,10-dicarboxylate

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / triethylamine / tetrahydrofuran; diethyl ether / 5 h / Ambient temperature

2: 14 percent / 0.8 M ammonia / CH₂Cl₂; methanol / 24 h / Ambient temperature

3: 90 percent / NEt₃ / acetonitrile / 48 h / Heating

With ammonium hydroxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile;

DOI:10.1016/S0040-4020(01)85265-0

upstream raw materials:

2-[3-(2-formylphenoxy)propoxy]benzaldehyde

acrylic acid methyl ester

Downstream raw materials:

2-[Acetoxy-(2-{3-[2-(1-acetoxy-2-methoxycarbonyl-allyl)-phenoxy]-propoxy}-phenyl)-methyl]-acrylic acid methyl ester