36193-65-4

Usage

Uses

Used in Pharmaceutical Industry:
1H-indole-2-carbonitrile is used as a key intermediate in the synthesis of various pharmaceutical compounds due to its potential biological activities. It is known for its anti-cancer, anti-inflammatory, and antimicrobial properties, making it a promising candidate for the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, 1H-indole-2-carbonitrile is utilized as a building block for the production of agrochemicals. Its unique reactivity and structure contribute to the development of effective and targeted agrochemicals for crop protection and pest control.
Used in Dye Industry:
1H-indole-2-carbonitrile is employed as a starting material in the synthesis of various dyes. Its versatile chemical properties allow for the creation of a wide range of dyes with different color characteristics and applications in various industries, such as textiles, plastics, and printing inks.

Upstream product

• 54698-11-2 1-methoxyindole 
• 151-50-8 potassium cyanide 
• 557-21-1 zinc(II) cyanide 
• 167558-54-5 2-(2,2-dibromo-vinyl)-phenylamine 
• 498-66-8 norbornene 
• 490039-75-3 N-(benzenesulfonyl)-3-iodoindole-2-carbonitrile 

Downstream Products

• 63071-71-6 indole-2-carbothioamide 
• 90539-84-7 1-benzoyl-2-cyanoindole 
• 116325-35-0 1-(Phenylsulfonyl)indole-2-carbonitrile 
• 51796-65-7 3-iodo-1H-indole-2-carbonitrile 
• 51796-62-4 2,2'-Dicyano-3,3'-bis 
• 878020-61-2 methyl (2-cyanoindol-1-yl)phenylacetate 
• 911132-62-2 1-(1-phenylethyl)indole-2-carbonitrile 
• 911132-63-3 (S)-2-cyano-1-(2-methoxy-1-phenylethyl)indole 
• 490039-75-3 N-(benzenesulfonyl)-3-iodoindole-2-carbonitrile 
• 111141-58-3 indole-2-carbonimidic acid-(N'-phenyl-hydrazide) 
• 1178572-09-2 C₁₉H₁₆N₂O 
• 1178572-14-9 C₂₁H₂₀N₂O 
• 1178572-03-6 N-benzoylmethyl-1H-indole-2-cyanide 
• 1178572-07-0 C₁₈H₁₄N₂O 

Relevant academic research and scientific papers

Palladium-catalyzed synthesis of 2-cyanoindoles from 2-gem-dihalovinylanilines

An efficient Pd(0)-catalyzed synthesis of 2-cyanoindoles from 2-gem-dihalovinylanilines is reported. Few methods have aimed to synthesize these scaffolds which are found in many natural products and have high bioactivity. This protocol features a robust c

Carbopalladation of nitriles: Synthesis of 2,3-diarylindenones and polycyclic aromatic ketones by the Pd-catalyzed annulation of alkynes and bicyclic alkenes by 2-iodoarenenitriles

2-Iodobenzonitrile, its derivatives, and various heterocyclic analogues undergo palladium(O)-catalyzed annulation onto diarylacetylenes or bicyclic alkenes to afford 2,3-diarylindenones and polycyclic aromatic ketones in very good to excellent yields. This reaction represents one of the first examples of the addition of an organopalladium moiety to the carbon-nitrogen triple bond of a nitrile. The reaction is compatible with a number of functional groups. A reaction mechanism, as well as a model accounting for the electronic effects of substituents on the aromatic ring of the nitrile, is proposed.

2-(Tosylamino)benzyltrimethylammonium halides as precursors of 2-substituted indoles

The reactions of 2-(tosylamino)benzyltrimethylammonium halides (1) with dimethylsulfonium 2-oxo-2-phenylethylide (6b), dimethylsulfonium 2-ethoxy-2-oxo-ethylide (6c) and dimethylsulfonium cyanomethylide (6d) are useful synthetic routes to 2-substituted indoles (8b-d). The relationship between reaction conditions and selectivity is discussed.

INTRODUCTION OF NUCLEOPHILES OR ETHYL GROUP TO THE INDOLE NUCLEUS THROUGH NUCLEOPHILIC SUBSTITUTION AND/OR RADICAL REACTIONS OF 1-METHOXYINDOLE-3- AND -2-CARBOXALDEHYDE

1-Methoxyindole-3- and -2-carboxaldehyde were found to undergo nucleophilic substitution and radical reactions resulting in the introduction of nucleophiles and/or ethyl group at the 2- or 3-position.