N4-(3-Bromo-4-fluorophenyl)-7-[3-(4-morpholinyl)propoxy]-4,6-quinazolinediamine

Base Information

Chemical Name:N4-(3-Bromo-4-fluorophenyl)-7-[3-(4-morpholinyl)propoxy]-4,6-quinazolinediamine
CAS No.:267243-67-4
Molecular Formula:C₂₁H₂₃BrFN₅O₂
Molecular Weight:476.348
Hs Code.:
DSSTox Substance ID:DTXSID101135976

Synonyms:DTXSID101135976;N4-(3-Bromo-4-fluorophenyl)-7-[3-(4-morpholinyl)propoxy]-4,6-quinazolinediamine;267243-67-4

Suppliers and Price of N4-(3-Bromo-4-fluorophenyl)-7-[3-(4-morpholinyl)propoxy]-4,6-quinazolinediamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of N4-(3-Bromo-4-fluorophenyl)-7-[3-(4-morpholinyl)propoxy]-4,6-quinazolinediamine

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:475.10192
Heavy Atom Count:30
Complexity:530

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COCCN1CCCOC2=C(C=C3C(=C2)N=CN=C3NC4=CC(=C(C=C4)F)Br)N

Technology Process of N4-(3-Bromo-4-fluorophenyl)-7-[3-(4-morpholinyl)propoxy]-4,6-quinazolinediamine

There total 5 articles about N4-(3-Bromo-4-fluorophenyl)-7-[3-(4-morpholinyl)propoxy]-4,6-quinazolinediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 267243-63-0
4-[N-(3-bromo-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline

: 267243-67-4
6-amino-4-[N-(3-bromo-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]quinazoline

Guidance literature:: With iron; acetic acid; In ethanol; for 0.5h; Heating;
DOI:10.1021/jm990482t

Reference yield:

: 4441-30-9
3-morpholin-4-ylpropan-1-ol

: 267243-67-4
6-amino-4-[N-(3-bromo-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]quinazoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: Na / tetrahydrofuran / 2 h / 20 °C

1.2: 39 percent / tetrahydrofuran

2.1: 91 percent / Fe; aq. HOAc / ethanol / 0.5 h / Heating

With sodium; iron; acetic acid; In tetrahydrofuran; ethanol; 1.1: deprotonation / 1.2: Substitution / 2.1: Reduction;
DOI:10.1021/jm990482t

Reference yield:

: 656-64-4
3-bromo-4-fluoroaniline

: 267243-67-4
6-amino-4-[N-(3-bromo-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]quinazoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: 89 percent / CH₂Cl₂; propan-2-ol / 0.5 h / 20 °C

2.1: Na / tetrahydrofuran / 2 h / 20 °C

2.2: 39 percent / tetrahydrofuran

3.1: 91 percent / Fe; aq. HOAc / ethanol / 0.5 h / Heating

With sodium; iron; acetic acid; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol; 1.1: Condensation / 2.1: deprotonation / 2.2: Substitution / 3.1: Reduction;
DOI:10.1021/jm990482t