4-[N-(3-bromo-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline

Base Information

• Chemical Name: 4-[N-(3-bromo-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline
• CAS No.: 267243-63-0
• Molecular Formula: C₂₁H₂₁BrFN₅O₄
• Molecular Weight: 506.331

Synonyms:4-[N-(3-bromo-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline

Chemical Property of 4-[N-(3-bromo-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline

Chemical Property:

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Technology Process of 4-[N-(3-bromo-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline

There total 3 articles about 4-[N-(3-bromo-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

3-morpholin-4-ylpropan-1-ol (4441-30-9) + 4-[N-(3-bromo-4-fluorophenyl)amino]-7-fluoro-6-nitroquinazoline (267243-44-7) → 4-[N-(3-bromo-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline (267243-63-0)

Guidance literature:

3-morpholin-4-ylpropan-1-ol; With sodium; In tetrahydrofuran; at 20 ℃; for 2h;

4-[N-(3-bromo-4-fluorophenyl)amino]-7-fluoro-6-nitroquinazoline; In tetrahydrofuran; Further stages.;

DOI:10.1021/jm990482t

Reference yield:

3-bromo-4-fluoroaniline (656-64-4) → 4-[N-(3-bromo-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline (267243-63-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 89 percent / CH₂Cl₂; propan-2-ol / 0.5 h / 20 °C

2.1: Na / tetrahydrofuran / 2 h / 20 °C

2.2: 39 percent / tetrahydrofuran

With sodium; In tetrahydrofuran; dichloromethane; isopropyl alcohol; 1.1: Condensation / 2.1: deprotonation / 2.2: Substitution;

DOI:10.1021/jm990482t

Reference yield:

4-chloro-7-fluoro-6-nitroquinazoline (162012-70-6) → 4-[N-(3-bromo-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline (267243-63-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 89 percent / CH₂Cl₂; propan-2-ol / 0.5 h / 20 °C

2.1: Na / tetrahydrofuran / 2 h / 20 °C

2.2: 39 percent / tetrahydrofuran

With sodium; In tetrahydrofuran; dichloromethane; isopropyl alcohol; 1.1: Condensation / 2.1: deprotonation / 2.2: Substitution;

DOI:10.1021/jm990482t

upstream raw materials:

3-morpholin-4-ylpropan-1-ol

4-[N-(3-bromo-4-fluorophenyl)amino]-7-fluoro-6-nitroquinazoline

3-bromo-4-fluoroaniline

4-chloro-7-fluoro-6-nitroquinazoline

Downstream raw materials:

6-amino-4-[N-(3-bromo-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]quinazoline

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