5-Ethylindole

Base Information

• Chemical Name: 5-Ethylindole
• CAS No.: 68742-28-9
• Molecular Formula: C10H11N
• Molecular Weight: 145.204
• Hs Code.: 2933990090
• Mol file: 68742-28-9.mol

Synonyms:5-Ethylindole;

Chemical Property of 5-Ethylindole

Chemical Property:

• Boiling Point: 281.88 °C at 760 mmHg
• PKA: 17.17±0.30(Predicted)
• Flash Point: 119.876 °C
• PSA: 15.79000
• Density: 1.078 g/cm³
• LogP: 2.73030
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

5-Ethylindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Ethylindole

There total 18 articles about 5-Ethylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

5-(2-(phenylsulfonyl)ethyl)-1H-indole (1225327-16-1) → 5-ethyl-1H-indole (68742-28-9)

Guidance literature:

With magnesium; In methanol; at 60 - 64 ℃; Inert atmosphere;

DOI:10.14233/ajchem.2017.20739

Reference yield: 85.0%

5-bromo-1H-indole (10075-50-0) + triethyl borane (97-94-9) → 5-ethyl-1H-indole (68742-28-9)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In tetrahydrofuran; Inert atmosphere; Reflux;

DOI:10.1002/adsc.200800630

Reference yield: 82.0%

5-ethynyl-1H-indole (889108-48-9) → 5-ethyl-1H-indole (68742-28-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 2h; under 750.06 Torr;

DOI:10.1016/j.bmc.2006.01.030

upstream raw materials:

5-ethyl-1H-indole-2-carboxylic acid

ethyl 5-ethylindole-2-carboxylate

Acetaldehyde p-ethylphenylhydrazone

5-ethylindole-2-carboxylic acid

Downstream raw materials:

(5-Ethyl-1H-indol-3-ylmethyl)-dimethyl-amine

2-(5-ethyl-1H-indol-3-yl)ethylamine

(R)-3-[(1-methyl-2-pyrrolidinyl)-methyl]-5-ethyl-1H-indole

indole

Refernces

• 1、 Rao, S. Venkat,Shrikant, H. Havale,Kumar, B. Sanjith,Krishna, G. Siva. "Magnesium catalyzed dephenylsulfonylation: Synthesis of 5-ethyl-1H-indole". . p. 2232 - 2234. Retrieved 2017/10/05.
• 2、 Wang, Bing,Sun, Hui-Xia,Sun, Zhi-Hua,Lin, Guo-Qiang. "Direct B-alkyl Suzuki-Miyaura cross-coupling of trialkyl-boranes with aryl bromides in the presence of unmasked acidic or basic functions and base-labile protections under mild non-aqueous conditions". experimental part. p. 415 - 422. Retrieved 2009/10/23.