2-debenzoyl-(2-p-fluorobenzoyl)-4-deacetyl-(4-d3-acetyl)-7-O-triethylsilylbaccatin III

Base Information

Chemical Name:2-debenzoyl-(2-p-fluorobenzoyl)-4-deacetyl-(4-d3-acetyl)-7-O-triethylsilylbaccatin III
CAS No.:925211-19-4
Molecular Formula:C₃₇H₅₁FO₁₁Si
Molecular Weight:721.865
Hs Code.:

Synonyms:2-debenzoyl-(2-p-fluorobenzoyl)-4-deacetyl-(4-d3-acetyl)-7-O-triethylsilylbaccatin III

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Chemical Property of 2-debenzoyl-(2-p-fluorobenzoyl)-4-deacetyl-(4-d3-acetyl)-7-O-triethylsilylbaccatin III

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Technology Process of 2-debenzoyl-(2-p-fluorobenzoyl)-4-deacetyl-(4-d3-acetyl)-7-O-triethylsilylbaccatin III

There total 8 articles about 2-debenzoyl-(2-p-fluorobenzoyl)-4-deacetyl-(4-d3-acetyl)-7-O-triethylsilylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 925211-18-3
2-debenzoyl-2-(p-fluorobenzoyl)-4-deacetyl-4-(d3-acetyl)baccatin III

: 994-30-9
triethylsilyl chloride

: 925211-19-4
2-debenzoyl-(2-p-fluorobenzoyl)-4-deacetyl-(4-d3-acetyl)-7-O-triethylsilylbaccatin III

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 0.5h;
DOI:10.1021/ja0656604

Reference yield:

: 925211-27-4
2-debenzoyl-2-(p-fluorobenzoyl)-1-dimethylsilyl-7,10,13-tri(triethylsilyl)-10-deacetylbaccatin

: 925211-19-4
2-debenzoyl-(2-p-fluorobenzoyl)-4-deacetyl-(4-d3-acetyl)-7-O-triethylsilylbaccatin III

Guidance literature:: Multi-step reaction with 4 steps

1.1: 66 percent / LHMDS / tetrahydrofuran / 3 h / 0 °C

2.1: 88 percent / HF*pyridine / tetrahydrofuran / 2 h / 20 °C

3.1: CeCl₃ / tetrahydrofuran / 0.17 h / 20 °C

3.2: 96 percent / tetrahydrofuran / 2 h / 20 °C

4.1: 94 percent / imidazole / dimethylformamide / 0.5 h

With 1H-imidazole; pyridine hydrogenfluoride; lithium hexamethyldisilazane; cerium(III) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja0656604

Reference yield:

: 245657-91-4
2-debenzoyl-2-(p-fluorobenzoyl)-7,10,13-tris(triethylsilyl)-10-deacetylbaccatin

: 925211-19-4
2-debenzoyl-(2-p-fluorobenzoyl)-4-deacetyl-(4-d3-acetyl)-7-O-triethylsilylbaccatin III

Guidance literature:: Multi-step reaction with 5 steps

1.1: 94 percent / imidazole / dimethylformamide / 1 h / 20 °C

2.1: 66 percent / LHMDS / tetrahydrofuran / 3 h / 0 °C

3.1: 88 percent / HF*pyridine / tetrahydrofuran / 2 h / 20 °C

4.1: CeCl₃ / tetrahydrofuran / 0.17 h / 20 °C

4.2: 96 percent / tetrahydrofuran / 2 h / 20 °C

5.1: 94 percent / imidazole / dimethylformamide / 0.5 h

With 1H-imidazole; pyridine hydrogenfluoride; lithium hexamethyldisilazane; cerium(III) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja0656604