Technology Process of 24-cyclohexyl-9,18-dimethyl-4,5,6,7,8,9-hexahydro-13,17:16,19-di(metheno)-1,10,4,9,11,18-benzoxathiatetraazacyclohenicosine-3,12(2H,11H,18H)-dione 10,10-dioxide
There total 11 articles about 24-cyclohexyl-9,18-dimethyl-4,5,6,7,8,9-hexahydro-13,17:16,19-di(metheno)-1,10,4,9,11,18-benzoxathiatetraazacyclohenicosine-3,12(2H,11H,18H)-dione 10,10-dioxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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1208129-83-2
24-cyclohexyl-9,18-dimethyl-4,5,6,7,8,9-hexahydro-13,17:16,19-di(metheno)-1,10,4,9,11,18-benzoxathiatetraazacyclohenicosine-3,12(2H,11H,18H)-dione 10,10-dioxide
- Guidance literature:
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With
N-ethyl-N,N-diisopropylamine; HATU;
In
tetrahydrofuran;
at 20 ℃;
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1208129-83-2
24-cyclohexyl-9,18-dimethyl-4,5,6,7,8,9-hexahydro-13,17:16,19-di(metheno)-1,10,4,9,11,18-benzoxathiatetraazacyclohenicosine-3,12(2H,11H,18H)-dione 10,10-dioxide
- Guidance literature:
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Multi-step reaction with 10 steps
1: potassium hydroxide / tetrahydrofuran
2: sodium hydride / tetrahydrofuran / 20 °C
3: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,2-dimethoxyethane; water / 12 h / 100 °C
4: potassium carbonate / acetonitrile / 20 °C
5: water; lithium hydroxide / tetrahydrofuran; methanol
6: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran
7: sulfonamide / 1,4-dioxane / 0.75 h / 100 °C
8: trifluoroacetic acid / dichloromethane / 20 °C
9: acetonitrile
10: 1,8-diazabicyclo[5.4.0]undec-7-ene
With
tetrakis(triphenylphosphine) palladium(0); sulfonamide; water; sodium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; potassium hydroxide; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;
3: Suzuki-Miyaura reaction;
DOI:10.1016/j.bmcl.2012.03.097
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1208129-83-2
24-cyclohexyl-9,18-dimethyl-4,5,6,7,8,9-hexahydro-13,17:16,19-di(metheno)-1,10,4,9,11,18-benzoxathiatetraazacyclohenicosine-3,12(2H,11H,18H)-dione 10,10-dioxide
- Guidance literature:
-
Multi-step reaction with 7 steps
1: potassium carbonate / acetonitrile / 20 °C
2: water; lithium hydroxide / tetrahydrofuran; methanol
3: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran
4: sulfonamide / 1,4-dioxane / 0.75 h / 100 °C
5: trifluoroacetic acid / dichloromethane / 20 °C
6: acetonitrile
7: 1,8-diazabicyclo[5.4.0]undec-7-ene
With
sulfonamide; water; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.03.097
