5-Iodo-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

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Chemical Name:5-Iodo-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one
CAS No.:114748-65-1
Molecular Formula:C₃₁H₂₈IN₃O₃S
Molecular Weight:649.552
Hs Code.:

Synonyms:5-Iodo-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

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Chemical Property of 5-Iodo-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

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Technology Process of 5-Iodo-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

There total 8 articles about 5-Iodo-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 114748-64-0
5-Iodo-4-methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine

: 114748-65-1
5-Iodo-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: With sodium 4-mercaptobenzoate; In N,N,N,N,N,N-hexamethylphosphoric triamide; toluene; for 4.5h; Heating;
DOI:10.1016/S0040-4039(00)80417-7

Reference yield:

: 98891-39-5
7-(2'-Desoxy-β-D-erythro-pentofuranosyl)-4-methoxy-2-methylthio-7H-pyrrolo<2,3-d>pyrimidin

: 114748-65-1
5-Iodo-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / DMAP, Et₃N / pyridine / 16.5 h / 65 °C

2: 1.) phenyl chlorothiocarbonate, DMAP; 2.) n-Bu₃SnH, AIBN / 1.) CH₂Cl₂, RT, 3 h; 2.) toluene, 105 deg C, 10 min

3: 96 percent / N-iodosuccinimide / dimethylformamide / 16 h / Ambient temperature

4: 97 percent / sodium thiocresolate / hexamethylphosphoric acid triamide; toluene / 4.5 h / Heating

With dmap; N-iodo-succinimide; sodium 4-mercaptobenzoate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; phenylcarbonochloridothioate; In pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)80417-7

Reference yield:

: 114748-63-9
4-Methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine

: 114748-65-1
5-Iodo-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / N-iodosuccinimide / dimethylformamide / 16 h / Ambient temperature

2: 97 percent / sodium thiocresolate / hexamethylphosphoric acid triamide; toluene / 4.5 h / Heating

With N-iodo-succinimide; sodium 4-mercaptobenzoate; In N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)80417-7