4-Methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:4-Methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine
CAS No.:114748-63-9
Molecular Formula:C₃₂H₃₁N₃O₃S
Molecular Weight:537.682
Hs Code.:

Synonyms:4-Methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Property of 4-Methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine

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Technology Process of 4-Methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine

There total 6 articles about 4-Methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98891-39-5
7-(2'-Desoxy-β-D-erythro-pentofuranosyl)-4-methoxy-2-methylthio-7H-pyrrolo<2,3-d>pyrimidin

: 114748-63-9
4-Methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / DMAP, Et₃N / pyridine / 16.5 h / 65 °C

2: 1.) phenyl chlorothiocarbonate, DMAP; 2.) n-Bu₃SnH, AIBN / 1.) CH₂Cl₂, RT, 3 h; 2.) toluene, 105 deg C, 10 min

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; phenylcarbonochloridothioate; In pyridine;
DOI:10.1016/S0040-4039(00)80417-7

Reference yield:

: 76-83-5
trityl chloride

: 114748-63-9
4-Methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / DMAP, Et₃N / pyridine / 16.5 h / 65 °C

2: 1.) phenyl chlorothiocarbonate, DMAP; 2.) n-Bu₃SnH, AIBN / 1.) CH₂Cl₂, RT, 3 h; 2.) toluene, 105 deg C, 10 min

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; phenylcarbonochloridothioate; In pyridine;
DOI:10.1016/S0040-4039(00)80417-7

Reference yield:

: 29877-76-7
4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidine

: 114748-63-9
4-Methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH; 2.) Rexyn^TM201 strongly basic ion exchange resin (hydroxide form) / 1.) CH₃CN, RT, 45 min; 2.) MeOH, reflux, 1.5 h

2: 94 percent / DMAP, Et₃N / pyridine / 16.5 h / 65 °C

3: 1.) phenyl chlorothiocarbonate, DMAP; 2.) n-Bu₃SnH, AIBN / 1.) CH₂Cl₂, RT, 3 h; 2.) toluene, 105 deg C, 10 min

With dmap; 2,2'-azobis(isobutyronitrile); Rexyn^TM201 strongly basic ion exchange resin (hydroxide form); tri-n-butyl-tin hydride; sodium hydride; triethylamine; phenylcarbonochloridothioate; In pyridine;
DOI:10.1016/S0040-4039(00)80417-7