2-(2,4-Dimethoxyphenyl)acetamide

Base Information

• Chemical Name: 2-(2,4-Dimethoxyphenyl)acetamide
• CAS No.: 666175-56-0
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.218
• DSSTox Substance ID: DTXSID601307627
• Mol file: 666175-56-0.mol

Synonyms:2-(2,4-dimethoxyphenyl)acetamide;666175-56-0;2,4-Dimethoxybenzeneacetamide;SCHEMBL3456256;DTXSID601307627;AKOS008031648;Z62734485

Chemical Property of 2-(2,4-Dimethoxyphenyl)acetamide

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 195.08954328
• Heavy Atom Count: 14
• Complexity: 196

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)CC(=O)N)OC

Technology Process of 2-(2,4-Dimethoxyphenyl)acetamide

There total 6 articles about 2-(2,4-Dimethoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2,4-dimethoxy-phenyl)-acetyl chloride (139445-84-4) → (2,4-dimethoxy-phenyl)-acetic acid amide (666175-56-0)

Guidance literature:

With 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; at 0 - 20 ℃;

DOI:10.1246/cl.150041

Reference yield:

(2,4-dimethoxyphenyl)acetonitrile (1891-11-8) → 2,4-dimethoxyphenylacetic acid (6496-89-5) + (2,4-dimethoxy-phenyl)-acetic acid amide (666175-56-0)

Guidance literature:

With potassium phosphate buffer; lyophilized Zea mays nitrilase ZmNIT₂ EC 3.5.5.1; In water; at 30 ℃; for 14h; pH=7.15; Title compound not separated from byproducts;

DOI:10.1016/j.tet.2006.04.069

Reference yield:

2,4-dimethoxyphenylacetic acid (6496-89-5) → (2,4-dimethoxy-phenyl)-acetic acid amide (666175-56-0)

Guidance literature:

With thionyl chloride; anschliessend Erhitzen mit NH₃;

upstream raw materials:

2,4-dimethoxyphenylacetic acid

ethyl (2,4-dimethoxyphenyl)acetate

2-diazo-1-(3,4-dimethoxyphenyl)ethanone

(2,4-dimethoxyphenyl)acetonitrile

Downstream raw materials:

(2,4-dimethoxyphenyl)acetonitrile

2,4-dimethoxyphenylacetic acid