(2,4-dimethoxyphenyl)acetonitrile

Base Information

• Chemical Name: (2,4-dimethoxyphenyl)acetonitrile
• CAS No.: 1891-11-8
• Molecular Formula: C10H11 N O2
• Molecular Weight: 177.203
• Mol file: 1891-11-8.mol

Synonyms:Acetonitrile, (2,4-dimethoxyphenyl)- (6CI,7CI,8CI);(2,4-Dimethoxyphenyl)acetonitrile; NSC 269437

Chemical Property of (2,4-dimethoxyphenyl)acetonitrile

Chemical Property:

• Vapor Pressure: 0.000892mmHg at 25°C
• Boiling Point: 304.1°Cat760mmHg
• Flash Point: 120.8°C
• Density: 1.082g/cm³

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2,4-dimethoxyphenyl)acetonitrile

There total 13 articles about (2,4-dimethoxyphenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-(2,4-dimethoxy-phenyl)-2-hydroxyimino-propionic acid (139109-55-0) → (2,4-dimethoxyphenyl)acetonitrile (1891-11-8)

Guidance literature:

With 1,1'-carbonyldiimidazole; In benzene; 1.) r.t., 15 min, 2.) 68-70 deg C, 1 h;

DOI:10.1248/cpb.39.3030

Reference yield: 90.0%

N-cyano-N-phenyl-p-toluenesulfonamide (55305-43-6) + 2,4-dimethoxyphenylacetic acid (6496-89-5) → (2,4-dimethoxyphenyl)acetonitrile (1891-11-8)

Guidance literature:

2,4-dimethoxyphenylacetic acid; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at 0 ℃; for 0.25h; Inert atmosphere;

N-cyano-N-phenyl-p-toluenesulfonamide; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 18h; Inert atmosphere;

With copper(II) oxide; In acetonitrile; at 85 ℃; for 0.5h;

DOI:10.1021/acs.joc.7b00033

Reference yield: 59.0%

(2,4-dimethoxyphenyl)zinc chloride (109384-40-9) + cyanomethyl bromide (590-17-0) → 2,2',4,4'-tetramethoxybiphenyl (3153-72-8) + (2,4-dimethoxyphenyl)acetonitrile (1891-11-8)

Guidance literature:

bis(acetylacetonate)nickel(II); cyclohexyldiphenylphosphine; In tetrahydrofuran; at 20 ℃; for 1h; Yields of byproduct given;

DOI:10.1055/s-1987-27834

upstream raw materials:

2,4 dimethoxybenzoic acid

potassium cyanide

(2,4-dimethoxy-phenyl)-acetaldehyde-oxime

(2,4-dimethoxy-phenyl)-acetic acid amide

Downstream raw materials:

2,4-dimethoxyphenylacetic acid

2,4,2',4'-tetramethoxy-deoxybenzoin

3-(2,4-dimethoxy-phenyl)-5,7-dihydroxy-2-methyl-chromen-4-one

5,7-diacetoxy-3-(2,4-dimethoxy-phenyl)-2-methyl-chromen-4-one

Refernces

• 1、 -. "PYRAZOLO [1,5-ALPHA] PYRIMIDINYL DERIVATIVES USEFUL AS CORTICOTROPIN-RELEASING FACTOR (CRF) RECEPTOR ANTAGONISTS". Page/Page column 42. . Retrieved 2008/06/13.
• 2、 Bhandari, Prabha,Crombie, Leslie,Daniels, Peter,Holden, Ian,Bruggen, Nicholas Van,Whiting, Donald A.. "Biosynthesis of the A/B/C/D-Ring System of the Rotenoid Amorphigenin by Amorpha fruticosa Seedlings". . p. 839 - 850. Retrieved 2007/10/02.