1891-11-8

Basic information

• Product Name: (2,4-dimethoxyphenyl)acetonitrile
• Synonyms: (2,4-Dimethoxyphenyl)acetonitrile; benzeneacetonitrile, 2,4-dimethoxy-
• CAS NO: 1891-11-8
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.1998
• Mol File: 1891-11-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 304.1°C at 760 mmHg
• Flash Point: 120.8°C
• Density: 1.082g/cm³
• Vapor Pressure: 0.000892mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: (2,4-dimethoxyphenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (2,4-dimethoxyphenyl)acetonitrile(1891-11-8)
• EPA Substance Registry System: (2,4-dimethoxyphenyl)acetonitrile(1891-11-8)

Safety Data

• Hazardous Substances Data: 1891-11-8(Hazardous Substances Data)

Usage

General Description

(2,4-dimethoxyphenyl)acetonitrile is a chemical compound with the molecular formula C10H11NO2. It is a nitrile derivative of 2,4-dimethoxyacetophenone, which is commonly used in organic synthesis and pharmaceutical manufacturing. (2,4-dimethoxyphenyl)acetonitrile is a colorless to yellowish liquid with a faint odor, and it is sparingly soluble in water but soluble in organic solvents. It has potential applications in the synthesis of various pharmaceuticals and organic compounds due to its versatile chemical reactivity and functional group composition. Additionally, (2,4-dimethoxyphenyl)acetonitrile has been studied for its biological activities, including its potential as an antimicrobial and antifungal agent.

Upstream product

• 109384-40-9 (2,4-dimethoxyphenyl)zinc chloride 
• 590-17-0 cyanomethyl bromide 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 6496-89-5 2,4-dimethoxyphenylacetic acid 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 863550-41-8 C₁₈H₂₁NO₅S 
• 92741-81-6 ethyl (2,4-dimethoxyphenyl)acetate 
• 139109-55-0 3-(2,4-dimethoxy-phenyl)-2-hydroxyimino-propionic acid 
• 666175-56-0 (2,4-dimethoxy-phenyl)-acetic acid amide 
• 1891-08-3 (2,4-dimethoxy-phenyl)-acetaldehyde-oxime 
• 91-52-1 2,4 dimethoxybenzoic acid 
• 151-50-8 potassium cyanide 

Downstream Products

• 94312-76-2 2,3-bis-(2,4-dimethoxy-phenyl)-3-oxo-propionitrile 
• 6496-89-5 2,4-dimethoxyphenylacetic acid 
• 1855-30-7 1-(2,4-dihydroxyphenyl)-2-(2,4-dimethoxyphenyl)ethanone 
• 7622-50-6 2,4,2',4'-tetramethoxy-deoxybenzoin 
• 38986-93-5 3-(2,4-dimethoxy-phenyl)-5,7-dihydroxy-2-methyl-chromen-4-one 
• 38987-07-4 5,7-diacetoxy-3-(2,4-dimethoxy-phenyl)-2-methyl-chromen-4-one 
• 1226181-93-6 C₁₀H₁₃NO₂S 
• 65975-51-1 2-(2,4-dimethoxyphenyl)-2-methylpropanenitrile 
• 58822-02-9 2',4',7-trimethoxyisoflavan 
• 7678-84-4 3-(2,4-dimethoxyphenyl)-7-methoxy-4H-chromen-4-one 
• 112863-89-5 4,7-diacetoxy-3-(2,4-dimethoxy-phenyl)-5-methoxy-coumarin 
• 132593-74-9 3-(2,4-dimethoxy-phenyl)-4,7-dihydroxy-5-methoxy-coumarin 
• 61503-83-1 3-(2,4-dimethoxyphenyl)-4-hydroxy-7-methoxy-1-benzopyran-2-one 
• 6506-29-2 3-(2,4-dimethoxy-phenyl)-4,7-dihydroxy-coumarin 

Relevant articles and documents

Development of Decarboxylative Cyanation Reactions for C-13/C-14 Carboxylic Acid Labeling Using an Electrophilic Cyanating Reagent

Degradation-reconstruction approaches for isotope labeling synthesis have been known for their remarkable efficiency, but applications are scarce due to some fundamental limitations of the chemistries developed to date. The decarboxylative cyanation reaction, as a degradation-reconstruction approach, is especially useful in rapid carboxylic acid carbon isotope labeling, however development toward its application as a widespread technique has stalled at the early stages due to numerous limitations which include somewhat narrow applicability. Employing the electrophilic cyanating reagent N-cyano-N-phenyl-p-toluenesulfonamide (NCTS) as the cyano source, efficient decarboxylative cyanation chemistry has been developed for aryl and alkyl carboxylic acids respectively with two rationally designed reaction pathways. The reactions provided good yields of nitrile products from carboxylic acids, with complete retention of isotopic purity from the [13CN]-NCTS used. The reaction conditions are relatively mild requiring no oxidant and no excess toxic heavy metal and the reagent [13/14CN]-NCTS is a stable, easy-to-handle crystalline solid that can be prepared quickly and effectively from the readily available [13/14C]-KCN. The following work describes this novel and efficient method for alkyl and aryl carboxylic acid isotopic labeling using a single reagent.

CRF RECEPTOR ANTAGONISTS, THEIR PREPARATIONS, THEIR PHARMACEUTICAL COMPOSITION AND THEIR USES

CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals. CRF receptor antagonists which are labeled with a posit

Degradation of 3-aryl-2-hydroxyiminopropionic acids into arylacetonitriles using 1,1'-carbonyldiimidazole or 2,2'-oxalyldi(o-sulfobenzimide)

1,1'-Carbonyldiimidazole (1) is a useful reagent for the preparation of arylacetonitriles (9) from 3-aryl-2-hydroxyiminopropionic acids (8), and 2,2'-oxalyldi (o-sulfobenzimide) (2) can also be used for this purpose under essentially neutral conditions.