N-[2-(cyclopropanecarbonyl)phenyl]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-[2-(cyclopropanecarbonyl)phenyl]-4-methylbenzenesulfonamide
• CAS No.: 20758-45-6
• Molecular Formula: C₁₇H₁₇NO₃S
• Molecular Weight: 315.393
• Mol file: 20758-45-6.mol

Synonyms:N-[2-(cyclopropanecarbonyl)phenyl]-4-methylbenzenesulfonamide

Chemical Property of N-[2-(cyclopropanecarbonyl)phenyl]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-[2-(cyclopropanecarbonyl)phenyl]-4-methylbenzenesulfonamide

There total 8 articles about N-[2-(cyclopropanecarbonyl)phenyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-toluenesulfonyl azide (941-55-9) + cyclopropyl phenyl ketone (3481-02-5) → N-[2-(cyclopropanecarbonyl)phenyl]-4-methylbenzenesulfonamide (20758-45-6)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; sodium acetate; silver(I) triflimide; In 1,2-dichloro-ethane; at 80 ℃; for 12h;

DOI:10.1002/chem.201301025

Reference yield: 28.0%

1-cyclopropyl-1-(2-(tosylamino)phenyl)methanol (1334483-49-6) → N-[2-(cyclopropanecarbonyl)phenyl]-4-methylbenzenesulfonamide (20758-45-6)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol5015398

Reference yield:

4-chloro-1-(2-N-tosylaminophenyl)-1-butanone + 2'-(tetrahydro-2-oxo-3-furoyl)-p-toluenesulfonanilide (209596-43-0) → N-[2-(cyclopropanecarbonyl)phenyl]-4-methylbenzenesulfonamide (20758-45-6)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In toluene;

upstream raw materials:

2'-(tetrahydro-2-oxo-3-furoyl)-p-toluenesulfonanilide

p-toluenesulfonyl chloride

4-toluenesulfonyl azide

cyclopropyl phenyl ketone

Downstream raw materials:

4-cyclopropylquinolin-3-yl(phenyl)methanone

N-[2-(1-cyclopropylvinyl)phenyl]-4-methylbenzenesulfonamide