N-[2-(1-cyclopropylvinyl)phenyl]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-[2-(1-cyclopropylvinyl)phenyl]-4-methylbenzenesulfonamide
• CAS No.: 1334483-22-5
• Molecular Formula: C₁₈H₁₉NO₂S
• Molecular Weight: 313.42
• Mol file: 1334483-22-5.mol

Synonyms:N-[2-(1-cyclopropylvinyl)phenyl]-4-methylbenzenesulfonamide

Chemical Property of N-[2-(1-cyclopropylvinyl)phenyl]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

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Technology Process of N-[2-(1-cyclopropylvinyl)phenyl]-4-methylbenzenesulfonamide

There total 13 articles about N-[2-(1-cyclopropylvinyl)phenyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-cyclopropyl-1-[2-(tosylamino)phenyl]ethanol (1334483-21-4) → N-[2-(1-cyclopropylvinyl)phenyl]-4-methylbenzenesulfonamide (1334483-22-5)

Guidance literature:

With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; In toluene; for 18h; Reflux; Inert atmosphere;

DOI:10.1002/chem.201101363

Reference yield: 66.0%

N-[2-(cyclopropanecarbonyl)phenyl]-4-methylbenzenesulfonamide (20758-45-6) + Methyltriphenylphosphonium bromide (1779-49-3) → N-[2-(1-cyclopropylvinyl)phenyl]-4-methylbenzenesulfonamide (1334483-22-5)

Guidance literature:

Methyltriphenylphosphonium bromide; With sodium hexamethyldisilazane; In tetrahydrofuran; at 78 ℃; for 0.5h; Inert atmosphere;

N-[2-(cyclopropanecarbonyl)phenyl]-4-methylbenzenesulfonamide; In tetrahydrofuran; at 25 ℃; for 11h; Inert atmosphere;

DOI:10.1021/ol5015398

Reference yield: 10.0%

1-cyclopropyl-1-[2-(tosylamino)phenyl]ethanol (1334483-21-4) → N-[2-(1-cyclopropylvinyl)phenyl]-4-methylbenzenesulfonamide (1334483-22-5) + 5-methyl-1-p-toluenesulfonyl-2,3-dihydro-1H-benzo[b]azepine

Guidance literature:

With [tris(para(trifluoromethyl)phenyl)phosphine]gold(I) chloride; silver trifluoromethanesulfonate; In 1,2-dichloro-ethane; for 18h; Reflux; Inert atmosphere;

DOI:10.1002/chem.201101363

upstream raw materials:

1-cyclopropyl-1-[2-(tosylamino)phenyl]ethanol

N-(2-acetylphenyl)-4-methylbenzenesulfonamide

2-aminoacetophenone

p-toluenesulfonyl chloride