Technology Process of ethyl 2-(3-cyano-4-methoxymethoxyphenyl)nicotinate
There total 5 articles about ethyl 2-(3-cyano-4-methoxymethoxyphenyl)nicotinate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium carbonate;
palladium diacetate; tris-(o-tolyl)phosphine;
In
1,2-dimethoxyethane; water;
at 80 ℃;
for 3h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: formic acid; hydroxylamine hydrochloride; sodium formate / 7 h / 100 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C
2.2: 0 - 20 °C
3.1: n-butyllithium; Triisopropyl borate / tetrahydrofuran; hexane / 21 h / -80 - 20 °C / Inert atmosphere
4.1: sodium carbonate / palladium diacetate; tris-(o-tolyl)phosphine / 1,2-dimethoxyethane; water / 3 h / 80 °C / Inert atmosphere
With
n-butyllithium; formic acid; Triisopropyl borate; hydroxylamine hydrochloride; potassium tert-butylate; sodium formate; sodium carbonate;
palladium diacetate; tris-(o-tolyl)phosphine;
In
tetrahydrofuran; 1,2-dimethoxyethane; hexane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / 24 h / Reflux
2: sodium carbonate / palladium diacetate; tris-(o-tolyl)phosphine / 1,2-dimethoxyethane; water / 3 h / 80 °C / Inert atmosphere
With
sodium carbonate;
palladium diacetate; toluene-4-sulfonic acid; tris-(o-tolyl)phosphine;
In
1,2-dimethoxyethane; water;
