4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(2,2,2-trifluoroethoxy)phenylacetic acid

Base Information

Chemical Name:4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(2,2,2-trifluoroethoxy)phenylacetic acid
CAS No.:220996-39-4
Molecular Formula:C₂₀H₂₆F₃NO₆
Molecular Weight:433.425
Hs Code.:

Synonyms:4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(2,2,2-trifluoroethoxy)phenylacetic acid

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Chemical Property of 4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(2,2,2-trifluoroethoxy)phenylacetic acid

Chemical Property:

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Technology Process of 4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(2,2,2-trifluoroethoxy)phenylacetic acid

There total 5 articles about 4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(2,2,2-trifluoroethoxy)phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220996-38-3
methyl 4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(2,2,2-trifluoroethoxy)phenyl-acetate

: 220996-39-4
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(2,2,2-trifluoroethoxy)phenylacetic acid

Guidance literature:: With sodium hydroxide; In methanol;
DOI:10.1016/S0960-894X(99)00181-X

Reference yield:

: 89-84-9
2',4'-dihydroxy-4-acetophenone

: 220996-39-4
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(2,2,2-trifluoroethoxy)phenylacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl azodicarboxylate, Ph₃P / tetrahydrofuran

2: Cs₂CO₃ / dimethylformamide

3: 1.) Tl(NO₃)3, 2.) Boc₂O, DIEA / 1.) MeOH, 2.) DMF

4: aq. NaOH / methanol

With sodium hydroxide; di-tert-butyl dicarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; thallium(III) nitrate; diethylazodicarboxylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(99)00181-X

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 220996-39-4
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(2,2,2-trifluoroethoxy)phenylacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl azodicarboxylate, Ph₃P / tetrahydrofuran

2: Cs₂CO₃ / dimethylformamide

3: 1.) Tl(NO₃)3, 2.) Boc₂O, DIEA / 1.) MeOH, 2.) DMF

4: aq. NaOH / methanol

With sodium hydroxide; di-tert-butyl dicarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; thallium(III) nitrate; diethylazodicarboxylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(99)00181-X