3-[5-(4-cyclobutyl[1,4]diazepane-1-carbonyl)pyridin-2-yloxy]benzonitrile hydrochloride

Base Information

Chemical Name:3-[5-(4-cyclobutyl[1,4]diazepane-1-carbonyl)pyridin-2-yloxy]benzonitrile hydrochloride
CAS No.:1245784-81-9
Molecular Formula:C₂₂H₂₄N₄O₂*ClH
Molecular Weight:412.919
Hs Code.:

Synonyms:3-[5-(4-cyclobutyl[1,4]diazepane-1-carbonyl)pyridin-2-yloxy]benzonitrile hydrochloride

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Chemical Property of 3-[5-(4-cyclobutyl[1,4]diazepane-1-carbonyl)pyridin-2-yloxy]benzonitrile hydrochloride

Chemical Property:

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Technology Process of 3-[5-(4-cyclobutyl[1,4]diazepane-1-carbonyl)pyridin-2-yloxy]benzonitrile hydrochloride

There total 10 articles about 3-[5-(4-cyclobutyl[1,4]diazepane-1-carbonyl)pyridin-2-yloxy]benzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[5-(4-cyclobutyl[1,4]diazepane-1-carbonyl)pyridin-2-yloxy]benzonitrile

: 1245784-81-9
3-[5-(4-cyclobutyl[1,4]diazepane-1-carbonyl)pyridin-2-yloxy]benzonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; at 20 - 40 ℃; Product distribution / selectivity;

Reference yield:

: 505-66-8
1,4-Diazacycloheptane

: 1245784-81-9
3-[5-(4-cyclobutyl[1,4]diazepane-1-carbonyl)pyridin-2-yloxy]benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-hexyllithium / tetrahydrofuran; hexane / 18.7 h / 0 - 20 °C

2.1: 1,1-dichloroethane / 1 h

2.2: 21.5 h

3.1: caesium carbonate / N,N-dimethyl acetamide / 20 h / 125 °C

4.1: hydrogenchloride / isopropyl alcohol / 2 h / 35 - 40 °C

With hydrogenchloride; n-hexyllithium; caesium carbonate; In tetrahydrofuran; 1,1-dichloroethane; hexane; N,N-dimethyl acetamide; isopropyl alcohol;
DOI:10.1021/op200005e

Reference yield:

: 49608-01-7
6-chloro-3-pyridinecarboxylic acid ethyl ester

: 1245784-81-9
3-[5-(4-cyclobutyl[1,4]diazepane-1-carbonyl)pyridin-2-yloxy]benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-hexyllithium / tetrahydrofuran; hexane / 18.7 h / 0 - 20 °C

2.1: 1,1-dichloroethane / 1 h

2.2: 21.5 h

3.1: caesium carbonate / N,N-dimethyl acetamide / 20 h / 125 °C

4.1: hydrogenchloride / isopropyl alcohol / 2 h / 35 - 40 °C

With hydrogenchloride; n-hexyllithium; caesium carbonate; In tetrahydrofuran; 1,1-dichloroethane; hexane; N,N-dimethyl acetamide; isopropyl alcohol;
DOI:10.1021/op200005e