(4S)-3-[(2S)-2-(4-fluorophenyl)propanoyl]-4-isopropyl-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4S)-3-[(2S)-2-(4-fluorophenyl)propanoyl]-4-isopropyl-1,3-oxazolidin-2-one
CAS No.:762297-74-5
Molecular Formula:C₁₅H₁₈FNO₃
Molecular Weight:279.311
Hs Code.:

Synonyms:(4S)-3-[(2S)-2-(4-fluorophenyl)propanoyl]-4-isopropyl-1,3-oxazolidin-2-one

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Chemical Property of (4S)-3-[(2S)-2-(4-fluorophenyl)propanoyl]-4-isopropyl-1,3-oxazolidin-2-one

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Technology Process of (4S)-3-[(2S)-2-(4-fluorophenyl)propanoyl]-4-isopropyl-1,3-oxazolidin-2-one

There total 3 articles about (4S)-3-[(2S)-2-(4-fluorophenyl)propanoyl]-4-isopropyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 762297-72-3
(4S)-3-[(4-fluorophenyl)acetyl]-4-isopropyl-1,3-oxazolidin-2-one

: 74-88-4
methyl iodide

: 762297-74-5
(4S)-3-[(2S)-2-(4-fluorophenyl)propanoyl]-4-isopropyl-1,3-oxazolidin-2-one

Guidance literature:: (4S)-3-[(4-fluorophenyl)acetyl]-4-isopropyl-1,3-oxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at -78 - -40 ℃; for 3h; Further stages.;
DOI:10.1021/jm060381c

Reference yield:

: 17016-83-0
(4S)-4-isopropyl-1,3-oxazolidin-2-one

: 762297-74-5
(4S)-3-[(2S)-2-(4-fluorophenyl)propanoyl]-4-isopropyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

1.2: 69 percent / tetrahydrofuran; hexane / 0.75 h / -78 - 0 °C

2.1: NaHMDS / tetrahydrofuran / 1 h / -78 °C

2.2: 81 percent / tetrahydrofuran / 3 h / -78 - -40 °C

With n-butyllithium; sodium hexamethyldisilazane; In tetrahydrofuran; hexane;
DOI:10.1021/jm060381c

Reference yield:

: 459-04-1
4-Fluorophenylacetyl chloride

: 762297-74-5
(4S)-3-[(2S)-2-(4-fluorophenyl)propanoyl]-4-isopropyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

1.2: 69 percent / tetrahydrofuran; hexane / 0.75 h / -78 - 0 °C

2.1: NaHMDS / tetrahydrofuran / 1 h / -78 °C

2.2: 81 percent / tetrahydrofuran / 3 h / -78 - -40 °C

With n-butyllithium; sodium hexamethyldisilazane; In tetrahydrofuran; hexane;
DOI:10.1021/jm060381c