(8R,10R)-8-((1H-imidazol-1-yl)methyl)-10-(5-chlorofuran-2-yl)-5-(3-fluorophenyl)-1,3-dimethyl-7,8-dihydro-1H-pyrimido[4',5:3,4]pyrrolo[2,1-c][1,4]oxazine-2,4(3H,10H)-dione

Base Information

Chemical Name:(8R,10R)-8-((1H-imidazol-1-yl)methyl)-10-(5-chlorofuran-2-yl)-5-(3-fluorophenyl)-1,3-dimethyl-7,8-dihydro-1H-pyrimido[4',5:3,4]pyrrolo[2,1-c][1,4]oxazine-2,4(3H,10H)-dione
CAS No.:1613623-53-2
Molecular Formula:C₂₅H₂₁ClFN₅O₄
Molecular Weight:509.924
Hs Code.:

(8R,10R)-8-((1H-imidazol-1-yl)methyl)-10-(5-chlorofuran-2-yl)-5-(3-fluorophenyl)-1,3-dimethyl-7,8-dihydro-1H-pyrimido[4',5:3,4]pyrrolo[2,1-c][1,4]oxazine-2,4(3H,10H)-dione

Synonyms:(8R,10R)-8-((1H-imidazol-1-yl)methyl)-10-(5-chlorofuran-2-yl)-5-(3-fluorophenyl)-1,3-dimethyl-7,8-dihydro-1H-pyrimido[4',5:3,4]pyrrolo[2,1-c][1,4]oxazine-2,4(3H,10H)-dione

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Chemical Property of (8R,10R)-8-((1H-imidazol-1-yl)methyl)-10-(5-chlorofuran-2-yl)-5-(3-fluorophenyl)-1,3-dimethyl-7,8-dihydro-1H-pyrimido[4',5:3,4]pyrrolo[2,1-c][1,4]oxazine-2,4(3H,10H)-dione

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Technology Process of (8R,10R)-8-((1H-imidazol-1-yl)methyl)-10-(5-chlorofuran-2-yl)-5-(3-fluorophenyl)-1,3-dimethyl-7,8-dihydro-1H-pyrimido[4',5:3,4]pyrrolo[2,1-c][1,4]oxazine-2,4(3H,10H)-dione

There total 7 articles about (8R,10R)-8-((1H-imidazol-1-yl)methyl)-10-(5-chlorofuran-2-yl)-5-(3-fluorophenyl)-1,3-dimethyl-7,8-dihydro-1H-pyrimido[4',5:3,4]pyrrolo[2,1-c][1,4]oxazine-2,4(3H,10H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (8R)-8-((1H-imidazol-1-yl)methyl)-10-(5-chlorofuran-2-yl)-5-(3-fluorophenyl)-1,3-dimethyl-7,8-dihydro-1H-pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]oxazine-2,4(3H,10H)-dione

: 1613623-53-2
(8R,10R)-8-((1H-imidazol-1-yl)methyl)-10-(5-chlorofuran-2-yl)-5-(3-fluorophenyl)-1,3-dimethyl-7,8-dihydro-1H-pyrimido[4',5:3,4]pyrrolo[2,1-c][1,4]oxazine-2,4(3H,10H)-dione

Guidance literature:: With Chiralpak AD-H 250x10 mm, 5 μm; In methanol; Resolution of racemate;

Reference yield:

: 1613622-55-1
(R)-6-(2,3-dihydroxypropyl)-5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

: 1613623-53-2
(8R,10R)-8-((1H-imidazol-1-yl)methyl)-10-(5-chlorofuran-2-yl)-5-(3-fluorophenyl)-1,3-dimethyl-7,8-dihydro-1H-pyrimido[4',5:3,4]pyrrolo[2,1-c][1,4]oxazine-2,4(3H,10H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: bismuth(lll) trifluoromethanesulfonate / ethanol / 0.42 h / 100 °C / Microwave irradiation

2: triethylamine; dmap / dichloromethane / 0.5 h / 0 °C

3: caesium carbonate / acetonitrile / 21.5 h / 80 - 85 °C

4: Chiralpak AD-H 250x10 mm, 5 μm / methanol / Resolution of racemate

With bismuth(lll) trifluoromethanesulfonate; dmap; caesium carbonate; triethylamine; In methanol; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1613622-54-0
5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

: 1613623-53-2
(8R,10R)-8-((1H-imidazol-1-yl)methyl)-10-(5-chlorofuran-2-yl)-5-(3-fluorophenyl)-1,3-dimethyl-7,8-dihydro-1H-pyrimido[4',5:3,4]pyrrolo[2,1-c][1,4]oxazine-2,4(3H,10H)-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: dibenzo-18-crown-6; sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C

1.2: 3.08 h / 0 - 20 °C

2.1: hydrogenchloride / diethyl ether; acetonitrile; water / 0.5 h / 20 °C

3.1: bismuth(lll) trifluoromethanesulfonate / ethanol / 0.42 h / 100 °C / Microwave irradiation

4.1: triethylamine; dmap / dichloromethane / 0.5 h / 0 °C

5.1: caesium carbonate / acetonitrile / 21.5 h / 80 - 85 °C

6.1: Chiralpak AD-H 250x10 mm, 5 μm / methanol / Resolution of racemate

With bismuth(lll) trifluoromethanesulfonate; hydrogenchloride; dmap; dibenzo-18-crown-6; sodium hydride; caesium carbonate; triethylamine; In methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;