N-(4-(2-Aminoacetyl)-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride

Base Information

• Chemical Name: N-(4-(2-Aminoacetyl)-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride
• CAS No.: 149436-41-9
• Molecular Formula: C16H18N2O5S^.HCl
• Molecular Weight: 386.85
• Hs Code.: 2935009090
• Mol file: 149436-41-9.mol

Synonyms:methanesulfonamide, N-[4-(2-aminoacetyl)-5-methoxy-2-phenoxyphenyl]-, hydrochloride (1:1);N-(4-Glycyl-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride (1:1);2-Amino-1-(2-methoxy-4-methanesulfonylamino-5-phenoxyphenyl)ethanone hydrochloride;

Chemical Property of N-(4-(2-Aminoacetyl)-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride

Chemical Property:

• Vapor Pressure: 3.73E-11mmHg at 25°C
• Boiling Point: 526 °C at 760 mmHg
• Flash Point: 271.9 °C
• PSA: 116.10000
• LogP: 4.65650
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

N-(4-(2-Aminoacetyl)-5-methoxy-2-phenoxyphenyl)-methanesulfonamide hydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-(2-Aminoacetyl)-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride

There total 5 articles about N-(4-(2-Aminoacetyl)-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-aminoacetonitrile hydrochloride (6011-14-9) + N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide (123664-84-6) → α-amino-2-methoxy-4-methanesulfonamido-5-phenoxyacetophenone hydrochloride (149436-41-9)

Guidance literature:

With hydrogenchloride; aluminium trichloride; In nitrobenzene; at 25 - 30 ℃; for 10h;

DOI:10.1248/cpb.48.131

Reference yield:

5-methoxy-1-nitro-2-phenoxybenzene (84594-95-6) → α-amino-2-methoxy-4-methanesulfonamido-5-phenoxyacetophenone hydrochloride (149436-41-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / 4N aq. HCl; Fe / ethanol / 0.33 h / 65 - 70 °C

2: 82 percent / pyridine / 1 h / 20 °C

3: 90 percent / AlCl₃; HCl / nitrobenzene / 10 h / 25 - 30 °C

With pyridine; hydrogenchloride; aluminium trichloride; iron; In ethanol; nitrobenzene; 1: Reduction / 2: Mesylation / 3: Acylation;

DOI:10.1248/cpb.48.131

Reference yield:

5-methoxy-2-phenoxyaniline (76838-72-7) → α-amino-2-methoxy-4-methanesulfonamido-5-phenoxyacetophenone hydrochloride (149436-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / pyridine / 1 h / 20 °C

2: 90 percent / AlCl₃; HCl / nitrobenzene / 10 h / 25 - 30 °C

With pyridine; hydrogenchloride; aluminium trichloride; In nitrobenzene; 1: Mesylation / 2: Acylation;

DOI:10.1248/cpb.48.131

upstream raw materials:

2-aminoacetonitrile hydrochloride

N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide

5-methoxy-1-nitro-2-phenoxybenzene

5-methoxy-2-phenoxyaniline

Downstream raw materials:

N-(2-(2-methoxy-4-(methylsulfonamido)-5-phenoxyphenyl)-2-oxoethyl)formamide

Refernces

• 1、 Inaba, Takihiro,Tanaka, Keiichi,Takeno, Ryuko,Nagaki, Hideyoshi,Yoshida, Chosaku,Takano, Shuntaro. "Synthesis and antiinflammatory activity of 7-methanesulfonylamino-6- phenoxychromones. Antiarthritic effect of the 3-formylamino compound (T-614) in chronic inflammatory disease models". . p. 131 - 139. Retrieved 2007/10/03.