(R)-5-benzoylamino-2-cyano-3-(4-fluorophenyl)-5-oxopentanoic acid methyl ester

Base Information

Chemical Name:(R)-5-benzoylamino-2-cyano-3-(4-fluorophenyl)-5-oxopentanoic acid methyl ester
CAS No.:609341-05-1
Molecular Formula:C₂₀H₁₇FN₂O₄
Molecular Weight:368.364
Hs Code.:

Synonyms:(R)-5-benzoylamino-2-cyano-3-(4-fluorophenyl)-5-oxopentanoic acid methyl ester

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Chemical Property of (R)-5-benzoylamino-2-cyano-3-(4-fluorophenyl)-5-oxopentanoic acid methyl ester

Chemical Property:

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Technology Process of (R)-5-benzoylamino-2-cyano-3-(4-fluorophenyl)-5-oxopentanoic acid methyl ester

There total 3 articles about (R)-5-benzoylamino-2-cyano-3-(4-fluorophenyl)-5-oxopentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105-34-0
methyl 2-cyanoacetate

: 609340-96-7
N-[3-(4-fluorophenyl)acryloyl]benzamide

: 609341-05-1
(R)-5-benzoylamino-2-cyano-3-(4-fluorophenyl)-5-oxopentanoic acid methyl ester

: (S)-5-benzylamino-2-cyano-3-(4-fluorophenyl)-5-oxopentanoic acid methyl ester

Guidance literature:: With [((S,S)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine(-2H))Al]2O; tert-butyl alcohol; In cyclohexane; at 20 ℃; for 54h; Title compound not separated from byproducts;
DOI:10.1021/ja037177o

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 609341-05-1
(R)-5-benzoylamino-2-cyano-3-(4-fluorophenyl)-5-oxopentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / DBU / tetrahydrofuran / 6 h / 23 °C

2: (S,S)-[(salen)Al]2O; t-BuOH / cyclohexane / 54 h / 20 °C

With [((S,S)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine(-2H))Al]2O; 1,8-diazabicyclo[5.4.0]undec-7-ene; tert-butyl alcohol; In tetrahydrofuran; cyclohexane;
DOI:10.1021/ja037177o

Reference yield:

: 247043-57-8
(2-benzoylamino-2-oxoethyl)phosphonic acid diethyl ester

: 609341-05-1
(R)-5-benzoylamino-2-cyano-3-(4-fluorophenyl)-5-oxopentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / DBU / tetrahydrofuran / 6 h / 23 °C

2: (S,S)-[(salen)Al]2O; t-BuOH / cyclohexane / 54 h / 20 °C

With [((S,S)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine(-2H))Al]2O; 1,8-diazabicyclo[5.4.0]undec-7-ene; tert-butyl alcohol; In tetrahydrofuran; cyclohexane;
DOI:10.1021/ja037177o