3-Allyloxy-4-methoxybenzaldehyde

Base Information

• Chemical Name: 3-Allyloxy-4-methoxybenzaldehyde
• CAS No.: 18075-40-6
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Hs Code.: 2912499000
• Mol file: 18075-40-6.mol

Synonyms:Benzaldehyde,3-(allyloxy)-4-methoxy- (8CI);Benzaldehyde, 4-methoxy-3-(2-propenyloxy)-(9CI);3-Allyloxy-4-methoxybenzaldehyde;4-Methoxy-3-(2-propenyloxy)benzaldehyde;

Chemical Property of 3-Allyloxy-4-methoxybenzaldehyde

Chemical Property:

• Vapor Pressure: 0.000504mmHg at 25°C
• Refractive Index: 1.537
• Boiling Point: 313.2 °C at 760 mmHg
• Flash Point: 134.2 °C
• PSA: 35.53000
• Density: 1.084 g/cm³
• LogP: 2.07250

Purity/Quality:

97% ^*data from raw suppliers

3-Allyloxy-4-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Allyloxy-4-methoxybenzaldehyde is an intermediate in synthesizing Diosmetin 3’,7-Diglucuronide (D485040), a metabolite of Diosmetin (D485000) which is a flavonoid often administered in the treatment of chronic venous insufficiency, hemorrhoids, and related affections.

Technology Process of 3-Allyloxy-4-methoxybenzaldehyde

There total 3 articles about 3-Allyloxy-4-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

isovanillin (621-59-0) + allyl bromide (106-95-6) → O-allylisovanillin (18075-40-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1016/S0040-4039(96)02435-5

Reference yield: 60.0%

4-hydroxy-3-(2-propenyloxy)benzaldehyde (52507-49-0) + methyl iodide (74-88-4) → O-allylisovanillin (18075-40-6)

Guidance literature:

4-hydroxy-3-(2-propenyloxy)benzaldehyde; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 3.5h; Further stages.;

DOI:10.1248/cpb.54.1299

Reference yield:

→ O-allylisovanillin (18075-40-6)

Guidance literature:

upstream raw materials:

isovanillin

allyl bromide

4-hydroxy-3-(2-propenyloxy)benzaldehyde

methyl iodide

Downstream raw materials:

(E)-3-(3-Allyloxy-4-methoxy-phenyl)-thioacrylamide

(E)-3-[3-(allyloxy)-4-methoxyphenyl]acrylic Acid

3-isopropoxy-4-methoxy-2-(prop-2'-enyl)benzaldehyde

2-allyl-3-hydroxy-4-methoxybenzaldehyde