(S)-(5-chloro-2-(pyrimidin-2-yl)phenyl)(6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)methanone

Base Information

Chemical Name:(S)-(5-chloro-2-(pyrimidin-2-yl)phenyl)(6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)methanone
CAS No.:1431663-71-6
Molecular Formula:C₂₄H₂₁ClF₃N₅O
Molecular Weight:487.912
Hs Code.:

Synonyms:(S)-(5-chloro-2-(pyrimidin-2-yl)phenyl)(6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)methanone

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Chemical Property of (S)-(5-chloro-2-(pyrimidin-2-yl)phenyl)(6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)methanone

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Technology Process of (S)-(5-chloro-2-(pyrimidin-2-yl)phenyl)(6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)methanone

There total 12 articles about (S)-(5-chloro-2-(pyrimidin-2-yl)phenyl)(6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1381972-84-4
5-chloro-2-(pyrimidin-2-yl)benzoic acid

: 1431663-88-5
C₁₃H₁₆F₃N₃

: 1431663-71-6
(S)-(5-chloro-2-(pyrimidin-2-yl)phenyl)(6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)methanone

Guidance literature:: 5-chloro-2-(pyrimidin-2-yl)benzoic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In 1,4-dioxane; at 25 ℃; for 0.5h;

C₁₃H₁₆F₃N₃; In 1,4-dioxane; at 50 - 70 ℃;

Reference yield:

: 1431322-86-9
(S)-1-(5-azaspiro[2.4]hept-6-yl)methanol

: 1431663-71-6
(S)-(5-chloro-2-(pyrimidin-2-yl)phenyl)(6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water / 2 h / 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C / Inert atmosphere; Cooling with ice

3.1: hydrazine hydrate / ethanol / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 80 - 100 °C / Microwave irradiation

5.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

6.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 1,4-dioxane / 0.5 h / 25 °C

6.2: 50 - 70 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; potassium carbonate; hydrazine hydrate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1262397-24-9
(S)-tert-butyl 6-((1,3-dioxoisoindolin-2-yl)methyl)-5-azaspiro[2.4]heptane-5-carboxylate

: 1431663-71-6
(S)-(5-chloro-2-(pyrimidin-2-yl)phenyl)(6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-5-azaspiro[2.4]heptan-5-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethanol / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 80 - 100 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

4.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 1,4-dioxane / 0.5 h / 25 °C

4.2: 50 - 70 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; potassium carbonate; hydrazine hydrate; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;