4,6-Dichloro-1H-indole

Base Information

Chemical Name:4,6-Dichloro-1H-indole
CAS No.:101495-18-5
Molecular Formula:C₈H₅Cl₂N
Molecular Weight:186.04
Hs Code.:2933990090
European Community (EC) Number:676-148-0
DSSTox Substance ID:DTXSID20560075
Wikidata:Q72466502
Mol file:101495-18-5.mol

Synonyms:4,6-Dichloro-1H-indole;101495-18-5;4,6-Dichloroindole;1H-INDOLE, 4,6-DICHLORO-;MFCD03094990;4,6-dichloro indole;SCHEMBL1022450;DTXSID20560075;4 pound not6-Dichloro-1H-indole;NIXGYRHZQFZCCV-UHFFFAOYSA-N;AMY24386;AKOS006278585;AC-9265;CS-W003013;DS-2161;PB23331;SY033201;A16276;EN300-118193;Q-101953;Z1198161528

Suppliers and Price of 4,6-Dichloro-1H-indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4,6-Dichloro-1H-indole
10g
$ 1320.00

SynQuest Laboratories
4,6-Dichloro-1H-indole 95%
250 mg
$ 240.00

Matrix Scientific
4,6-Dichloro-1H-indole 95+%
1g
$ 528.00

Labseeker
4,6-Dichloro-1H-indole 97
10g
$ 2200.00

Labseeker
4,6-Dichloro-1H-indole 97
50g
$ 4550.00

Crysdot
4,6-Dichloro-1H-indole 97%
5g
$ 465.00

Crysdot
4,6-Dichloro-1H-indole 97%
10g
$ 812.00

Chemenu
4,6-Dichloro-1H-indole 95%+
10g
$ 767.00

Chemenu
4,6-Dichloro-1H-indole 95%+
5g
$ 439.00

Chemenu
4,6-Dichloro-1H-indole 95%+
1g
$ 158.00

Total 35 raw suppliers

Chemical Property of 4,6-Dichloro-1H-indole

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.695
Boiling Point:328.146 °C at 760 mmHg
PKA:15.20±0.30(Predicted)
Flash Point:182.227 °C
PSA：15.79000
Density:1.479 g/cm³
LogP:3.47470
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:0
Rotatable Bond Count:0
Exact Mass:184.9799046
Heavy Atom Count:11
Complexity:151

Purity/Quality:

99%, ^*data from raw suppliers

4,6-Dichloro-1H-indole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CNC2=C1C(=CC(=C2)Cl)Cl
Uses 4,6-Dichloro-1H-indole is a dichlorinated indole used in the preparation of various biologically active compounds such as trypase inhibitors and inhibitors of serotonin, norepinephrine, and dopamine r euptake. 4,6-Dichloro-1H-indole is a dichlorinated indole used in the preparation of various biologically active compounds such as trypase inhibitors and inhibitors of serotonin, norepinephrine, and dopamine reuptake.

Technology Process of 4,6-Dichloro-1H-indole

There total 7 articles about 4,6-Dichloro-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1391575-68-0
2-(2-bromo-4,6-dichlorophenyl)acetaldehyde

: 101495-18-5
4,6-dichloro-1H-indole

Guidance literature:: With copper(I) oxide; ammonium hydroxide; In 1-methyl-pyrrolidin-2-one; water; at 50 ℃; for 2h;
DOI:10.1021/ja305660a

Reference yield:

: 101861-63-6
4,6-dichloro-1H-indole-2-carboxylic acid

: 101495-18-5
4,6-dichloro-1H-indole

Guidance literature:: With quinoline; copper oxide-chromium oxide;

Reference yield:

: 697-86-9
2,4-dichloro-6-bromoaniline

: 101495-18-5
4,6-dichloro-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / water; acetone

1.2: 0.03 h / Sonication

2.1: copper(I) oxide; ammonium hydroxide / 1-methyl-pyrrolidin-2-one; water / 2 h / 50 °C

With copper(I) oxide; hydrogenchloride; ammonium hydroxide; In 1-methyl-pyrrolidin-2-one; water; acetone;
DOI:10.1021/ja305660a