(2S,3S,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

Base Information

Chemical Name:(2S,3S,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol
CAS No.:184488-70-8
Molecular Formula:C₂₂H₄₀O₄Si
Molecular Weight:396.643
Hs Code.:

Synonyms:(2S,3S,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

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Chemical Property of (2S,3S,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

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Technology Process of (2S,3S,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

There total 6 articles about (2S,3S,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1-{(1S,2R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-methyl-butoxymethyl}-4-methoxy-benzene

: 184488-70-8
(2S,3S,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; for 6h; Ambient temperature;
DOI:10.1021/ja961374o

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 184488-70-8
(2S,3S,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / NaH

2: 1.) O₃, 2.) Me₂S

4: lutidine

5: 83 percent / HF*pyridine / tetrahydrofuran / 6 h / Ambient temperature

With dimethylsulfide; lutidine; sodium hydride; pyridine hydrogenfluoride; ozone; In tetrahydrofuran;
DOI:10.1021/ja961374o

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 184488-70-8
(2S,3S,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 48percent aq. HBr / 0.5 h / Ambient temperature

2: 90 percent / NaH

3: 1.) O₃, 2.) Me₂S

5: lutidine

6: 83 percent / HF*pyridine / tetrahydrofuran / 6 h / Ambient temperature

With dimethylsulfide; lutidine; hydrogen bromide; sodium hydride; pyridine hydrogenfluoride; ozone; In tetrahydrofuran;
DOI:10.1021/ja961374o