N-benzyl-(3S,4R)-3,4-dihydroxy-2,5-pyrrolidinedione

Base Information

• Chemical Name: N-benzyl-(3S,4R)-3,4-dihydroxy-2,5-pyrrolidinedione
• CAS No.: 1028903-71-0
• Molecular Formula: C₁₁H₁₁NO₄
• Molecular Weight: 221.213
• Mol file: 1028903-71-0.mol

Synonyms:N-benzyl-(3S,4R)-3,4-dihydroxy-2,5-pyrrolidinedione

Chemical Property of N-benzyl-(3S,4R)-3,4-dihydroxy-2,5-pyrrolidinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-benzyl-(3S,4R)-3,4-dihydroxy-2,5-pyrrolidinedione

There total 5 articles about N-benzyl-(3S,4R)-3,4-dihydroxy-2,5-pyrrolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-benzyl-1H-pyrrole-2,5-dione (1631-26-1) → N-benzyl-(3S,4R)-3,4-dihydroxy-2,5-pyrrolidinedione (1028903-71-0)

Guidance literature:

With 2-Picolinic acid; manganese(II) perchlorate hexahydrate; dihydrogen peroxide; sodium acetate; In water; acetone; at 0 - 20 ℃;

DOI:10.1039/c0ob00102c

Reference yield: 76.0%

meso-tartaric acid (147-73-9,138508-61-9) + benzylamine (100-46-9) → N-benzyl-(3S,4R)-3,4-dihydroxy-2,5-pyrrolidinedione (1028903-71-0)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; at 190 ℃; for 6h; Dean-Stark;

DOI:10.1016/j.bmcl.2017.04.078

Reference yield:

2-Picolinic acid (98-98-6) + 1-benzyl-1H-pyrrole-2,5-dione (1631-26-1) → N-benzyl-(3S,4R)-3,4-dihydroxy-2,5-pyrrolidinedione (1028903-71-0)

Guidance literature:

With manganese(II) perchlorate hexahydrate; dihydrogen peroxide; sodium acetate; In water; acetone; at 0 - 20 ℃; for 16h;

DOI:10.1016/j.ejmech.2018.12.032

upstream raw materials:

1-benzyl-1H-pyrrole-2,5-dione

meso-tartaric acid

benzylamine

2-Picolinic acid

Downstream raw materials:

N-benzyl-(3S,4R)-3,4-(cyclohexylidenedioxy)-2,5-pyrrolidinedione

(+/-)-N-benzyl-(3S,4R,5S)-3,4-(cyclohexylidenedioxy)-5-hydroxy-2-pyrrolidinone

(+/-)-N-benzyl-(3S,4R,5R)-3,4-(cyclohexylidenedioxy)-5-hydroxy-2-pyrrolidinone

(+/-)-N-benzyl-(3S,4R,5R)-3,4-(cyclohexylidenedioxy)-5-acetoxy-2-pyrrolidinone