5-(4-methoxyphenyl)-4-methyl-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine

Base Information

Chemical Name:5-(4-methoxyphenyl)-4-methyl-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine
CAS No.:198551-05-2
Molecular Formula:C₂₄H₂₆N₄O₂
Molecular Weight:402.496
Hs Code.:

Synonyms:5-(4-methoxyphenyl)-4-methyl-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine

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Chemical Property of 5-(4-methoxyphenyl)-4-methyl-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine

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Technology Process of 5-(4-methoxyphenyl)-4-methyl-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine

There total 4 articles about 5-(4-methoxyphenyl)-4-methyl-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 50-01-1
guanidine hydrochloride

: 198554-59-5
2-(4-methoxyphenyl)-1-[1-(phenylcarbonyl)piperidin-4-yl]butane-1,3-dione

: 1085917-50-5
2-(4-methoxyphenyl)-1-[1-(phenylcarbonyl)piperidin-4-yl]ethanone

: 198551-05-2
5-(4-methoxyphenyl)-4-methyl-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine

Guidance literature:: With potassium carbonate; In 1,4-dioxane; at 100 ℃; for 10h;
DOI:10.1016/j.bmc.2008.09.059

Reference yield:

: 5274-99-7
1-benzoylisonipecotic acid

: 198551-05-2
5-(4-methoxyphenyl)-4-methyl-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CHCl₃ / Heating

2: LDA / tetrahydrofuran / -70 °C

3: 7 percent / K₂CO₃; pyridine / 110 °C

With pyridine; thionyl chloride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; chloroform; 1: Chlorination / 2: Condensation / 3: Cyclization;
DOI:10.1016/S0960-894X(00)00227-4

Reference yield:

: 115755-50-5
1-benzoyl-4-piperidinecarbonyl chloride

: 198551-05-2
5-(4-methoxyphenyl)-4-methyl-6-[1-(phenylcarbonyl)piperidin-4-yl]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: LDA / tetrahydrofuran / -70 °C

2: 7 percent / K₂CO₃; pyridine / 110 °C

With pyridine; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1: Condensation / 2: Cyclization;
DOI:10.1016/S0960-894X(00)00227-4