2-(4-methoxyphenyl)-1-[1-(phenylcarbonyl)piperidin-4-yl]butane-1,3-dione

Base Information

Chemical Name:2-(4-methoxyphenyl)-1-[1-(phenylcarbonyl)piperidin-4-yl]butane-1,3-dione
CAS No.:198554-59-5
Molecular Formula:C₂₃H₂₅NO₄
Molecular Weight:379.456
Hs Code.:

Synonyms:2-(4-methoxyphenyl)-1-[1-(phenylcarbonyl)piperidin-4-yl]butane-1,3-dione

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Chemical Property of 2-(4-methoxyphenyl)-1-[1-(phenylcarbonyl)piperidin-4-yl]butane-1,3-dione

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Technology Process of 2-(4-methoxyphenyl)-1-[1-(phenylcarbonyl)piperidin-4-yl]butane-1,3-dione

There total 2 articles about 2-(4-methoxyphenyl)-1-[1-(phenylcarbonyl)piperidin-4-yl]butane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 122-84-9
4-methoxybenzyl methyl ketone

: 115755-50-5
1-benzoyl-4-piperidinecarbonyl chloride

: 198554-59-5
2-(4-methoxyphenyl)-1-[1-(phenylcarbonyl)piperidin-4-yl]butane-1,3-dione

: 198554-58-4
4-(4-methoxyphenyl)-1-[1-(phenylcarbonyl)piperidin-4-yl]butane-1,3-dione

Guidance literature:: 4-methoxybenzyl methyl ketone; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

1-benzoyl-4-piperidinecarbonyl chloride; In tetrahydrofuran; hexane; at -78 ℃; for 2.5h;
DOI:10.1016/j.bmc.2008.09.059

Reference yield:

: 5274-99-7
1-benzoylisonipecotic acid

: 198554-59-5
2-(4-methoxyphenyl)-1-[1-(phenylcarbonyl)piperidin-4-yl]butane-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / CHCl₃ / Heating

2: LDA / tetrahydrofuran / -70 °C

With thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran; chloroform; 1: Chlorination / 2: Condensation;
DOI:10.1016/S0960-894X(00)00227-4