ethyl 5-<8-<(benzyloxycarbonyl)amino>oct-1-en-2-yl>oxazoline-4-carboxylate

Base Information

Chemical Name:ethyl 5-<8-<(benzyloxycarbonyl)amino>oct-1-en-2-yl>oxazoline-4-carboxylate
CAS No.:134477-42-2
Molecular Formula:C₂₂H₃₀N₂O₅
Molecular Weight:402.491
Hs Code.:

Synonyms:ethyl 5-<8-<(benzyloxycarbonyl)amino>oct-1-en-2-yl>oxazoline-4-carboxylate

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Chemical Property of ethyl 5-<8-<(benzyloxycarbonyl)amino>oct-1-en-2-yl>oxazoline-4-carboxylate

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Technology Process of ethyl 5-<8-<(benzyloxycarbonyl)amino>oct-1-en-2-yl>oxazoline-4-carboxylate

There total 6 articles about ethyl 5-<8-<(benzyloxycarbonyl)amino>oct-1-en-2-yl>oxazoline-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 2999-46-4
Ethyl isocyanoacetate

: 134477-41-1
8-<(benzyloxycarbonyl)amino>-2-methyleneoctanal

: 134477-42-2
ethyl 5-<8-<(benzyloxycarbonyl)amino>oct-1-en-2-yl>oxazoline-4-carboxylate

Guidance literature:: With copper(I) oxide; In toluene; at 40 ℃; for 3h;
DOI:10.1021/jm00075a029

Reference yield:

: 2,10-diamino-4-phosphonomethyl-dec-3-enoic acid ethyl ester

: 19008-71-0
8-aminooctan-1-ol

: 2999-46-4
Ethyl isocyanoacetate

: 134477-41-1
8-<(benzyloxycarbonyl)amino>-2-methyleneoctanal

: 134477-42-2
ethyl 5-<8-<(benzyloxycarbonyl)amino>oct-1-en-2-yl>oxazoline-4-carboxylate

Guidance literature:: In toluene;

Reference yield:

: 19008-71-0
8-aminooctan-1-ol

: 134477-42-2
ethyl 5-<8-<(benzyloxycarbonyl)amino>oct-1-en-2-yl>oxazoline-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / NaHCO₃ / acetone; H₂O / 21 h / Ambient temperature

2: 1.) oxalyl chloride, DMSO, 2.) N-ethyldiisopropylamine / 1.) CH₂Cl₂, -60 to -50 deg C, 30 min, 2.) CH₂Cl₂, -50 deg C, 1 h

3: piperazine, AcOH / H₂O / 1 h / Heating

4: 33 percent / Cu₂O / toluene / 3 h / 40 °C

With piperazine; copper(I) oxide; oxalyl dichloride; sodium hydrogencarbonate; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In water; acetone; toluene;
DOI:10.1021/jm00075a029