1-(1-benzyl-3-indolyl)-1-(6-methoxy-4-trifluoromethanesulfonyloxy-3-pyridinyl)ethane

Base Information

Chemical Name:1-(1-benzyl-3-indolyl)-1-(6-methoxy-4-trifluoromethanesulfonyloxy-3-pyridinyl)ethane
CAS No.:872171-02-3
Molecular Formula:C₂₄H₂₁F₃N₂O₄S
Molecular Weight:490.503
Hs Code.:

Synonyms:1-(1-benzyl-3-indolyl)-1-(6-methoxy-4-trifluoromethanesulfonyloxy-3-pyridinyl)ethane

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Chemical Property of 1-(1-benzyl-3-indolyl)-1-(6-methoxy-4-trifluoromethanesulfonyloxy-3-pyridinyl)ethane

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Technology Process of 1-(1-benzyl-3-indolyl)-1-(6-methoxy-4-trifluoromethanesulfonyloxy-3-pyridinyl)ethane

There total 10 articles about 1-(1-benzyl-3-indolyl)-1-(6-methoxy-4-trifluoromethanesulfonyloxy-3-pyridinyl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 872171-01-2
1-(1-benzyl-3-indolyl)-1-(4-hydroxy-6-methoxy-3-pyridinyl)ethane

: 358-23-6
trifluoromethylsulfonic anhydride

: 872171-02-3
1-(1-benzyl-3-indolyl)-1-(6-methoxy-4-trifluoromethanesulfonyloxy-3-pyridinyl)ethane

Guidance literature:: With triethylamine; In dichloromethane; at -78 ℃; for 1h;
DOI:10.3987/COM-05-10522

Reference yield:

: 91591-88-7
2,4,6-trimethoxypyridine

: 872171-02-3
1-(1-benzyl-3-indolyl)-1-(6-methoxy-4-trifluoromethanesulfonyloxy-3-pyridinyl)ethane

Guidance literature:: Multi-step reaction with 9 steps

1.1: 98 percent / TiCl₄ / CH₂Cl₂ / 18 h / 20 °C

2.1: 94 percent / 2CuO*Cr₂O₃ / quinoline / 0.5 h / 180 °C

3.1: 47 percent / BBr₃ / CH₂Cl₂ / 2 h / 0 °C

4.1: 94 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

5.1: 85 percent / HCOONH₄ / Pd(PPh₃)4 / methanol / 2 h / Heating

6.1: 88 percent / BBr₃ / CH₂Cl₂ / 2 h / -20 °C

7.1: n-BuLi / hexane; tetrahydrofuran / 20 °C

7.2: 72 percent / hexane; tetrahydrofuran / 4 h / 0 °C

8.1: 68 percent / H₂ / PtO₂ / ethanol / 6 h

9.1: 88 percent / Et₃N / CH₂Cl₂ / 1 h / -78 °C

With chromium(III) oxide; n-butyllithium; hydrogen; ammonium formate; boron tribromide; titanium tetrachloride; triethylamine; copper(II) oxide; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; quinoline; methanol; ethanol; hexane; dichloromethane; 1.1: Friedel-Crafts reaction;
DOI:10.3987/COM-05-10522

Reference yield:

: 151054-77-2
1-benzylindole-2,3-dicarboxylic anhydride

: 872171-02-3
1-(1-benzyl-3-indolyl)-1-(6-methoxy-4-trifluoromethanesulfonyloxy-3-pyridinyl)ethane

Guidance literature:: Multi-step reaction with 9 steps

1.1: 98 percent / TiCl₄ / CH₂Cl₂ / 18 h / 20 °C

2.1: 94 percent / 2CuO*Cr₂O₃ / quinoline / 0.5 h / 180 °C

3.1: 47 percent / BBr₃ / CH₂Cl₂ / 2 h / 0 °C

4.1: 94 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

5.1: 85 percent / HCOONH₄ / Pd(PPh₃)4 / methanol / 2 h / Heating

6.1: 88 percent / BBr₃ / CH₂Cl₂ / 2 h / -20 °C

7.1: n-BuLi / hexane; tetrahydrofuran / 20 °C

7.2: 72 percent / hexane; tetrahydrofuran / 4 h / 0 °C

8.1: 68 percent / H₂ / PtO₂ / ethanol / 6 h

9.1: 88 percent / Et₃N / CH₂Cl₂ / 1 h / -78 °C

With chromium(III) oxide; n-butyllithium; hydrogen; ammonium formate; boron tribromide; titanium tetrachloride; triethylamine; copper(II) oxide; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; quinoline; methanol; ethanol; hexane; dichloromethane; 1.1: Friedel-Crafts reaction;
DOI:10.3987/COM-05-10522