2,4,6-Trimethoxypyridine

Base Information

• Chemical Name: 2,4,6-Trimethoxypyridine
• CAS No.: 91591-88-7
• Molecular Formula: C8H11 N O3
• Molecular Weight: 169.18
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00457535
• Nikkaji Number: J2.239.609I
• Wikidata: Q82280408
• Mol file: 91591-88-7.mol

Synonyms:2,4,6-trimethoxypyridine;91591-88-7;2,4,6-trimethoxy-pyridine;SCHEMBL3401912;DTXSID00457535;ISUYTITXRVKOQA-UHFFFAOYSA-N;MFCD11044393;AKOS006309960;SB54545;WS-02504;CS-0195657;FT-0717032;H11782

Chemical Property of 2,4,6-Trimethoxypyridine

Chemical Property:

• PSA: 40.58000
• LogP: 1.10740
• Storage Temp.: 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 169.07389321
• Heavy Atom Count: 12
• Complexity: 120

Purity/Quality:

99% ^*data from raw suppliers

2,4,6-Trimethoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=NC(=C1)OC)OC

Technology Process of 2,4,6-Trimethoxypyridine

There total 11 articles about 2,4,6-Trimethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methanol (67-56-1) + 2,4,6-trichloropyridine (16063-69-7) → 2,4,6-trimethoxypyridine (91591-88-7)

Guidance literature:

With sodium; at 140 ℃; for 3.5h; Heating;

Reference yield: 54.0%

methanol (67-56-1) + 2,4,6-trichloropyridine (16063-69-7) → 2,4,6-trimethoxypyridine (91591-88-7) + 4-chloro-2,6-dimethoxypyridine (62616-14-2) + 2-chloro-4,6-dimethoxypyridine (108279-89-6)

Guidance literature:

With sodium; for 7h; Heating;

Reference yield: 27.0%

3,5-dichloro-2,4,6-trimethoxypyridine (2412-97-7) → 3-chloro-2,4,6-trimethoxypyridine + 2,4,6-trimethoxypyridine (91591-88-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 6h; Heating;

DOI:10.1016/j.jfluchem.2005.01.018

upstream raw materials:

2,4,6-trichloropyridine

sodium methylate

methanol

2,4,6-tribromopyridine

Downstream raw materials:

(1-benzyl-1H-indol-3-yl)-(4-hydroxy-6-methoxy-2-methyl-pyridin-3-yl)-methanone

(1-benzyl-1H-indol-3-yl)-(4,6-dimethoxy-2-methyl-pyridin-3-yl)-methanone

1-benzyl-3-(4,6-dimethoxy-2-trifluoromethanesulfonyloxynicotinoyl)indole

1-benzyl-3-(2-hydroxy-4,6-dimethoxynicotinoyl)indole