5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(1H-1,2,4-triazol-1-yl)benzonitrile

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Chemical Name:5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(1H-1,2,4-triazol-1-yl)benzonitrile
CAS No.:1072915-59-3
Molecular Formula:C₂₀H₁₄Cl₂F₃N₅
Molecular Weight:452.266
Hs Code.:

Synonyms:5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(1H-1,2,4-triazol-1-yl)benzonitrile

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Chemical Property of 5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(1H-1,2,4-triazol-1-yl)benzonitrile

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Technology Process of 5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(1H-1,2,4-triazol-1-yl)benzonitrile

There total 4 articles about 5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(1H-1,2,4-triazol-1-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288-88-0
1,2,4-Triazole

: 1072915-82-2
5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-fluorobenzonitrile

: 1072915-59-3
5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(1H-1,2,4-triazol-1-yl)benzonitrile

Guidance literature:: 1,2,4-Triazole; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-fluorobenzonitrile; In N,N-dimethyl-formamide; for 6h; Heating / reflux;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 1072915-59-3
5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(1H-1,2,4-triazol-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

2.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 3 h / Heating / reflux

2.2: 2 h / 60 °C

3.1: sodium t-butanolate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 2 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

4.2: 6 h / Heating / reflux

With carbonochloridic acid 1-chloro-ethyl ester; sodium hydride; trifluoroacetic acid; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1025025-19-7
rac-3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidine

: 1072915-59-3
5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(1H-1,2,4-triazol-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium t-butanolate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 2 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

2.2: 6 h / Heating / reflux

With sodium hydride; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; toluene;