methyl 6-methyl-3-phenethyl-2-(propylcarbamoyl)-1H-indole-5-carboxylate

Base Information

• Chemical Name: methyl 6-methyl-3-phenethyl-2-(propylcarbamoyl)-1H-indole-5-carboxylate
• CAS No.: 1015464-49-9
• Molecular Formula: C₂₃H₂₆N₂O₃
• Molecular Weight: 378.471
• Mol file: 1015464-49-9.mol

Synonyms:methyl 6-methyl-3-phenethyl-2-(propylcarbamoyl)-1H-indole-5-carboxylate

Chemical Property of methyl 6-methyl-3-phenethyl-2-(propylcarbamoyl)-1H-indole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-methyl-3-phenethyl-2-(propylcarbamoyl)-1H-indole-5-carboxylate

There total 1 articles about methyl 6-methyl-3-phenethyl-2-(propylcarbamoyl)-1H-indole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

propylamine (107-10-8,42939-71-9) + 5-(methoxycarbonyl)-6-methyl-3-phenethyl-1H-indole-2-carboxylic acid (1015464-47-7) → methyl 6-methyl-3-phenethyl-2-(propylcarbamoyl)-1H-indole-5-carboxylate (1015464-49-9)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2007.12.038

Reference yield:

methyl 6-methyl-3-phenethyl-2-(propylcarbamoyl)-1H-indole-5-carboxylate (1015464-49-9) → C22H24N2O3 (1015464-65-9)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; methanol; at 95 ℃; for 4h;

DOI:10.1016/j.bmcl.2007.12.038 DOI:10.1016/j.bmcl.2007.12.039

upstream raw materials:

propylamine

5-(methoxycarbonyl)-6-methyl-3-phenethyl-1H-indole-2-carboxylic acid

Downstream raw materials:

C₂₂H₂₄N₂O₃