5-(methoxycarbonyl)-6-methyl-3-phenethyl-1H-indole-2-carboxylic acid

Base Information

• Chemical Name: 5-(methoxycarbonyl)-6-methyl-3-phenethyl-1H-indole-2-carboxylic acid
• CAS No.: 1015464-47-7
• Molecular Formula: C₂₀H₁₉NO₄
• Molecular Weight: 337.375
• Mol file: 1015464-47-7.mol

Synonyms:5-(methoxycarbonyl)-6-methyl-3-phenethyl-1H-indole-2-carboxylic acid

Chemical Property of 5-(methoxycarbonyl)-6-methyl-3-phenethyl-1H-indole-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 5-(methoxycarbonyl)-6-methyl-3-phenethyl-1H-indole-2-carboxylic acid

There total 1 articles about 5-(methoxycarbonyl)-6-methyl-3-phenethyl-1H-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methyl 4-amino-3-iodo-6-methylbenzoate (672293-33-3) + 2-oxo-5-phenylpentanoic acid (88768-11-0) → 5-(methoxycarbonyl)-6-methyl-3-phenethyl-1H-indole-2-carboxylic acid (1015464-47-7)

Guidance literature:

With diaza[2.2.2]bicyclooctane; palladium diacetate; In N,N-dimethyl-formamide; at 95 ℃; for 20h;

DOI:10.1016/j.bmcl.2007.12.038 DOI:10.1016/j.bmcl.2007.12.039

Reference yield: 89.0%

propylamine (107-10-8,42939-71-9) + 5-(methoxycarbonyl)-6-methyl-3-phenethyl-1H-indole-2-carboxylic acid (1015464-47-7) → methyl 6-methyl-3-phenethyl-2-(propylcarbamoyl)-1H-indole-5-carboxylate (1015464-49-9)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2007.12.038

Reference yield: 45.0%

5-(methoxycarbonyl)-6-methyl-3-phenethyl-1H-indole-2-carboxylic acid (1015464-47-7) + β-alanine benzyl ester p-toluenesulfonate (27019-47-2) → methyl 2-[3-(benzyloxy)-3-oxopropylcarbamoyl]-6-methyl-3-phenethyl-1H-indole-5-carboxylate (1016170-85-6)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2007.12.038

upstream raw materials:

methyl 4-amino-3-iodo-6-methylbenzoate

2-oxo-5-phenylpentanoic acid

Downstream raw materials:

methyl 6-methyl-3-phenethyl-2-(propylcarbamoyl)-1H-indole-5-carboxylate

methyl 2-[3-(benzyloxy)-3-oxopropylcarbamoyl]-6-methyl-3-phenethyl-1H-indole-5-carboxylate

methyl 6-methyl-2-(2-methylbutylcarbamoyl)-3-phenethyl-1H-indole-5-carboxylate

C₂₆H₃₀N₂O₃