4-methoxybenzyl N-allyl thiocarbamate

Base Information

• Chemical Name: 4-methoxybenzyl N-allyl thiocarbamate
• CAS No.: 1616487-09-2
• Molecular Formula: C₁₂H₁₅NO₂S
• Molecular Weight: 237.323
• Mol file: 1616487-09-2.mol

Synonyms:4-methoxybenzyl N-allyl thiocarbamate

Chemical Property of 4-methoxybenzyl N-allyl thiocarbamate

Chemical Property:

Purity/Quality:

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Technology Process of 4-methoxybenzyl N-allyl thiocarbamate

There total 1 articles about 4-methoxybenzyl N-allyl thiocarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-Methoxybenzyl alcohol (105-13-5) + N-allyl isothiocyanate (57-06-7,58391-87-0) → 4-methoxybenzyl N-allyl thiocarbamate (1616487-09-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 50 ℃; for 1h; Reagent/catalyst; Temperature; Time; Microwave irradiation; Molecular sieve;

DOI:10.1080/00397911.2014.894526

Reference yield: 85.0%

4-methoxybenzyl N-allyl thiocarbamate (1616487-09-2) + methyl 2,3,4-tri-O-benzoyl-α-D-galactopyranoside (101194-17-6) → 5-bromomethyl-thiazolidin-2-one (89033-67-0) + 1,2:3,4-di-O-isopropylidene-6-O-(4-metoxybenzylo)-α-D-galactopyranose

Guidance literature:

With N-Bromosuccinimide; tetraethylammonium trifluoromethanesulphonate; trifluoroacetic acid; In dichloromethane; at -24 ℃; for 0.1h; Molecular sieve;

DOI:10.1080/00397911.2014.894526

Reference yield: 84.0%

4-methoxybenzyl N-allyl thiocarbamate (1616487-09-2) + (2R,3R,4S,5R,6S)-4,5-bis(benzyloxy)-2-((tert-butyldimethylsilyloxy)methyl)-6-methoxytetrahydro-2H-pyran-3-ol (111727-15-2) → 5-bromomethyl-thiazolidin-2-one (89033-67-0) + methyl 2,3-di-O-benzyl-6-O-tert-butyldimethylsilyl-4-O-p-methoxybenzyl-α-D-glucopyranoside (495378-99-9)

Guidance literature:

With N-Bromosuccinimide; tetraethylammonium trifluoromethanesulphonate; trifluoroacetic acid; In dichloromethane; at -24 ℃; for 0.1h; Molecular sieve;

DOI:10.1080/00397911.2014.894526

upstream raw materials:

4-Methoxybenzyl alcohol

N-allyl isothiocyanate

Downstream raw materials:

5-bromomethyl-thiazolidin-2-one

2-((4-methoxybenzyloxy)methyl)oxirane

1,2:5,6-di-O-isopropylidene-3-O-(4-methoxybenzyl)-α-D-glucofuranose

5-(4-methoxybenzyloxymethyl)-2,2,7,7-tetramethyl-(3aR,5R,5aS,8aS,8bR)-perhydrodi-1,3-dioxolo[4,5-b:4',5'-d]pyran