1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-5-methoxy-methyl ester

Base Information

• Chemical Name: 1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-5-methoxy-methyl ester
• CAS No.: 136694-54-7
• Molecular Formula: C₁₉H₂₇NO₃S
• Molecular Weight: 349.494
• Mol file: 136694-54-7.mol

Synonyms:1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-5-methoxy-methyl ester

Chemical Property of 1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-5-methoxy-methyl ester

Chemical Property:

• PSA: 76.62000
• Density: 1.13
• LogP: 4.17270

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-5-methoxy-methyl ester

There total 3 articles about 1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-5-methoxy-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

methyl 5-(t-butylthio)-2,2-dimethyl-4-oxopentanoate + 4-Methoxyphenylhydrazine (3471-32-7) → methyl 3-<3-(tert-butylthio)-5-methoxyindol-2-yl>-2,2-dimethylpropanoate (136694-54-7)

Guidance literature:

In tert-butyl alcohol; for 24h; Heating;

DOI:10.1021/jm00071a008

Reference yield:

methyl 5-(t-butylthio)-2,2-dimethyl-4-oxopentanoate → methyl 3-<3-(tert-butylthio)-5-methoxyindol-2-yl>-2,2-dimethylpropanoate (136694-54-7)

Guidance literature:

With hydrogenchloride; In t BuOH; hexane; ethyl acetate;

Reference yield:

4-methoxyphenylhydrazine hydrochloride (19501-58-7) + methyl 5-(t-butylthio)-2,2-dimethyl-4-oxopentanoate → methyl 3-<3-(tert-butylthio)-5-methoxyindol-2-yl>-2,2-dimethylpropanoate (136694-54-7)

Guidance literature:

In ethyl acetate; toluene; tert-butyl alcohol;

upstream raw materials:

4-Methoxyphenylhydrazine

4-methoxyphenylhydrazine hydrochloride

Downstream raw materials:

3-[1-(3-Methoxy-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-2,2-dimethyl-propionic acid 3-methoxy-benzyl ester

2,2-Dimethyl-3-[4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-1-pyridin-2-ylmethyl-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-propionic acid pyridin-2-ylmethyl ester

methyl 3-<1-(4-chlorobenzyl)-4-methyl-6-<<(5-phenylpyridin-2-yl)methyl>thio>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

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