3-endo-(8-(2-[(4,4-difluorocyclohexylmethyl)amino]-ethyl)-8-azabicyclo[3.2.1]oct-3-yl)-2-hydroxybenzamide

Base Information

Chemical Name:3-endo-(8-(2-[(4,4-difluorocyclohexylmethyl)amino]-ethyl)-8-azabicyclo[3.2.1]oct-3-yl)-2-hydroxybenzamide
CAS No.:1123661-33-5
Molecular Formula:C₂₃H₃₃F₂N₃O₂
Molecular Weight:421.531
Hs Code.:

Synonyms:3-endo-(8-(2-[(4,4-difluorocyclohexylmethyl)amino]-ethyl)-8-azabicyclo[3.2.1]oct-3-yl)-2-hydroxybenzamide

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Chemical Property of 3-endo-(8-(2-[(4,4-difluorocyclohexylmethyl)amino]-ethyl)-8-azabicyclo[3.2.1]oct-3-yl)-2-hydroxybenzamide

Chemical Property:

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Technology Process of 3-endo-(8-(2-[(4,4-difluorocyclohexylmethyl)amino]-ethyl)-8-azabicyclo[3.2.1]oct-3-yl)-2-hydroxybenzamide

There total 2 articles about 3-endo-(8-(2-[(4,4-difluorocyclohexylmethyl)amino]-ethyl)-8-azabicyclo[3.2.1]oct-3-yl)-2-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[3-endo-(3-carbamoyl-2-hydroxy-phenyl)-8-aza-bicyclo[3.2.1]oct-8-yl]-ethyl-(4,4-difluoro-cyclohexylmethyl)-carbamic acid benzyl ester trifluoroacetate

: 1123661-33-5
3-endo-(8-(2-[(4,4-difluorocyclohexylmethyl)amino]-ethyl)-8-azabicyclo[3.2.1]oct-3-yl)-2-hydroxybenzamide

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; Product distribution / selectivity;

Reference yield:

: 1123661-42-6
(4,4-difluoro-cyclohexylmethyl)-(2-oxo-ethyl)-carbamic acid tert-butyl ester

: 1123661-10-8
3-endo-(8-azabicyclo[3.2.1]oct-3-yl)-2-hydroxybenzamide trifluoroacetate

: 1123661-33-5
3-endo-(8-(2-[(4,4-difluorocyclohexylmethyl)amino]-ethyl)-8-azabicyclo[3.2.1]oct-3-yl)-2-hydroxybenzamide

Guidance literature:: (4,4-difluoro-cyclohexylmethyl)-(2-oxo-ethyl)-carbamic acid tert-butyl ester; 3-endo-(8-azabicyclo[3.2.1]oct-3-yl)-2-hydroxybenzamide trifluoroacetate; With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h;

With trifluoroacetic acid; In dichloromethane; for 0.5h; Product distribution / selectivity;

Reference yield:

: 133481-13-7
lithium (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

: 1123661-33-5
3-endo-(8-(2-[(4,4-difluorocyclohexylmethyl)amino]-ethyl)-8-azabicyclo[3.2.1]oct-3-yl)-2-hydroxybenzamide

: 76-05-1
trifluoroacetic acid

: 1123662-03-2
3-endo-(8-(2-[(4,4-difluoro-cyclohexylmethyl)-((S)-2,3-dihydroxy-1-oxo-propyl)-amino]-ethyl)-8-aza-bicyclo[3.2.1]oct-3-yl)-2-hydroxy-benzamide trifluoroacetate

Guidance literature:: lithium (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate; 3-endo-(8-(2-[(4,4-difluorocyclohexylmethyl)amino]-ethyl)-8-azabicyclo[3.2.1]oct-3-yl)-2-hydroxybenzamide; With HATU; In N,N-dimethyl-formamide;

With water; acetic acid; at 70 ℃;

trifluoroacetic acid;