Technology Process of 5-Chloro-5'-[2-(4'-formyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde
There total 16 articles about 5-Chloro-5'-[2-(4'-formyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
aluminum oxide; pyridinium chlorochromate;
In
dichloromethane;
at 20 ℃;
for 24h;
DOI:10.1055/s-2002-35629
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 98 percent / 1 h / Heating
2: 79 percent / N,N'-dichloropiperazine / aq. H2SO4 / 1 h / 20 °C
3: 95 percent / aq. NaOH / 2 h / Heating
4: 96 percent / p-TosOH / toluene / 24 h / Heating
5: 68 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C
6: 81 percent / aq. Na2CO3 / Pd(PPh3)4 / ethanol; toluene / 24 h / Heating
7: 72 percent / K2CO3; 18-crown-6 / CH2Cl2 / 24 h / Heating
8: 76 percent / H2; Et3N / 5 percent Pd/C / ethyl acetate / 24 h / 2625.21 Torr
9: LiAlH4 / diethyl ether / 12 h / Heating
10: aq. AcOH / 15 h / 20 °C
11: 85 percent / PCC/Al2O3 / CH2Cl2 / 24 h / 20 °C
With
pyridine; N,N'-dichloropiperazine; aluminum oxide; sodium hydroxide; lithium aluminium tetrahydride; 18-crown-6 ether; hydrogen; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; pyridinium chlorochromate;
palladium on activated charcoal; tetrakis(triphenylphosphine) palladium(0);
In
diethyl ether; ethanol; dichloromethane; sulfuric acid; ethyl acetate; toluene;
6: Suzuki reaction / 7: Wittig reaction;
DOI:10.1055/s-2002-35629
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 60 percent / Br2 / acetic acid / 24 h / 80 °C
2: 80 percent / NaOH / 0.17 h / 100 °C
3: 77 percent / p-TosOH / toluene / 24 h / Heating
4: 84 percent / K3PO4 / Pd(PPh3)4 / dimethylformamide / 24 h / 80 °C
5: 72 percent / K2CO3; 18-crown-6 / CH2Cl2 / 24 h / Heating
6: 76 percent / H2; Et3N / 5 percent Pd/C / ethyl acetate / 24 h / 2625.21 Torr
7: LiAlH4 / diethyl ether / 12 h / Heating
8: aq. AcOH / 15 h / 20 °C
9: 85 percent / PCC/Al2O3 / CH2Cl2 / 24 h / 20 °C
With
aluminum oxide; sodium hydroxide; potassium phosphate; lithium aluminium tetrahydride; 18-crown-6 ether; hydrogen; bromine; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; pyridinium chlorochromate;
palladium on activated charcoal; tetrakis(triphenylphosphine) palladium(0);
In
diethyl ether; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene;
4: Suzuki reaction / 5: Wittig reaction;
DOI:10.1055/s-2002-35629
![5-chloro-5'-[2-(4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde](/Databaselist/images/loading.webp)
