5-chloro-5'-[2-(4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde

Base Information

Chemical Name:5-chloro-5'-[2-(4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde
CAS No.:511295-17-3
Molecular Formula:C₃₂H₃₁ClO₆
Molecular Weight:547.048
Hs Code.:

Synonyms:5-chloro-5'-[2-(4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde

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Chemical Property of 5-chloro-5'-[2-(4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde

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Technology Process of 5-chloro-5'-[2-(4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde

There total 15 articles about 5-chloro-5'-[2-(4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 621-59-0
isovanillin

: 511295-17-3
5-chloro-5'-[2-(4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde

Guidance literature:: Multi-step reaction with 10 steps

1: 98 percent / 1 h / Heating

2: 79 percent / N,N'-dichloropiperazine / aq. H₂SO₄ / 1 h / 20 °C

3: 95 percent / aq. NaOH / 2 h / Heating

4: 96 percent / p-TosOH / toluene / 24 h / Heating

5: 68 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

6: 81 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / ethanol; toluene / 24 h / Heating

7: 72 percent / K₂CO₃; 18-crown-6 / CH₂Cl₂ / 24 h / Heating

8: 76 percent / H₂; Et₃N / 5 percent Pd/C / ethyl acetate / 24 h / 2625.21 Torr

9: LiAlH₄ / diethyl ether / 12 h / Heating

10: aq. AcOH / 15 h / 20 °C

With pyridine; N,N'-dichloropiperazine; sodium hydroxide; lithium aluminium tetrahydride; 18-crown-6 ether; hydrogen; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; ethanol; dichloromethane; sulfuric acid; ethyl acetate; toluene; 6: Suzuki reaction / 7: Wittig reaction;
DOI:10.1055/s-2002-35629

Reference yield:

: 2420-16-8
4-hydroxy-3-chlorobenzaldehyde

: 511295-17-3
5-chloro-5'-[2-(4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1: 60 percent / Br₂ / acetic acid / 24 h / 80 °C

2: 80 percent / NaOH / 0.17 h / 100 °C

3: 77 percent / p-TosOH / toluene / 24 h / Heating

4: 84 percent / K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 24 h / 80 °C

5: 72 percent / K₂CO₃; 18-crown-6 / CH₂Cl₂ / 24 h / Heating

6: 76 percent / H₂; Et₃N / 5 percent Pd/C / ethyl acetate / 24 h / 2625.21 Torr

7: LiAlH₄ / diethyl ether / 12 h / Heating

8: aq. AcOH / 15 h / 20 °C

With sodium hydroxide; potassium phosphate; lithium aluminium tetrahydride; 18-crown-6 ether; hydrogen; bromine; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene; 4: Suzuki reaction / 5: Wittig reaction;
DOI:10.1055/s-2002-35629

Reference yield:

: 54246-06-9
3-chloro-5-hydroxy-4-methoxybenzaldehyde

: 511295-17-3
5-chloro-5'-[2-(4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / p-TosOH / toluene / 24 h / Heating

2: 68 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

3: 81 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / ethanol; toluene / 24 h / Heating

4: 72 percent / K₂CO₃; 18-crown-6 / CH₂Cl₂ / 24 h / Heating

5: 76 percent / H₂; Et₃N / 5 percent Pd/C / ethyl acetate / 24 h / 2625.21 Torr

6: LiAlH₄ / diethyl ether / 12 h / Heating

7: aq. AcOH / 15 h / 20 °C

With pyridine; lithium aluminium tetrahydride; 18-crown-6 ether; hydrogen; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; ethanol; dichloromethane; ethyl acetate; toluene; 3: Suzuki reaction / 4: Wittig reaction;
DOI:10.1055/s-2002-35629