1-Aminopyrrolidin-2-one hydrochloride

Base Information

• Chemical Name: 1-Aminopyrrolidin-2-one hydrochloride
• CAS No.: 20386-22-5
• Molecular Formula: C4H8N2O^.HCl
• Molecular Weight: 136.581
• Hs Code.: 2933790090
• Mol file: 20386-22-5.mol

Synonyms:2-Pyrrolidinone,1-amino-, monohydrochloride (8CI,9CI);1-Aminopyrrolidin-2-one hydrochloride;N-Amino-2-pyrrolidinone hydrochloride;

Chemical Property of 1-Aminopyrrolidin-2-one hydrochloride

Chemical Property:

• Melting Point: 227 °C at 760 mmHg
• Boiling Point: 91.1 °C
• PSA: 46.33000
• LogP: 0.92270
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

1-Aminopyrrolidin-2-one Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Aminopyrrolidin-2-one Hydrochloride is used for the optimization of dihydropyrrolopyrazole series for transforming the growth factor-β type I receptor kinase domain inhibitor and also for the discovery of an orally bioavailable antitumor agent.

Technology Process of 1-Aminopyrrolidin-2-one hydrochloride

There total 2 articles about 1-Aminopyrrolidin-2-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-<(diphenylmethylene)amino>pyrrolidin-2-one (79289-48-8) → 1-aminopyrrolidin-2-one hydrochloride (20386-22-5)

Guidance literature:

With hydrogenchloride; In water; for 1.5h; Heating / reflux;

Reference yield:

→ 1-aminopyrrolidin-2-one hydrochloride (20386-22-5)

Guidance literature:

Reference yield: 80.0%

1-bromo-2-(phenylethenyl)benzene (21375-88-2) + 1-aminopyrrolidin-2-one hydrochloride (20386-22-5) → 1-(2-phenyl-indol-1-yl)pyrrolidin-2-one (1264670-28-1)

Guidance literature:

With caesium carbonate; palladium dichloride; tri tert-butylphosphoniumtetrafluoroborate; In N,N-dimethyl-formamide; at 110 ℃; for 20h; Inert atmosphere;

DOI:10.1039/c0cc03584j

upstream raw materials:

1-<(diphenylmethylene)amino>pyrrolidin-2-one

Downstream raw materials:

3-ethoxycarbonyl-2-phenyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole

1-(2-phenyl-indol-1-yl)pyrrolidin-2-one

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