(E)-ethyl 1-(2-(2-bromovinyl)phenyl)-1H-1,2,3-triazole-4-carboxylate

Base Information

• Chemical Name: (E)-ethyl 1-(2-(2-bromovinyl)phenyl)-1H-1,2,3-triazole-4-carboxylate
• CAS No.: 1259940-08-3
• Molecular Formula: C₁₃H₁₂BrN₃O₂
• Molecular Weight: 322.161
• Mol file: 1259940-08-3.mol

Synonyms:(E)-ethyl 1-(2-(2-bromovinyl)phenyl)-1H-1,2,3-triazole-4-carboxylate

Chemical Property of (E)-ethyl 1-(2-(2-bromovinyl)phenyl)-1H-1,2,3-triazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (E)-ethyl 1-(2-(2-bromovinyl)phenyl)-1H-1,2,3-triazole-4-carboxylate

There total 5 articles about (E)-ethyl 1-(2-(2-bromovinyl)phenyl)-1H-1,2,3-triazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(E)-1-azido-2-(2-bromovinyl)benzene (1207516-57-1) + propynoic acid ethyl ester (623-47-2) → (E)-ethyl 1-(2-(2-bromovinyl)phenyl)-1H-1,2,3-triazole-4-carboxylate (1259940-08-3)

Guidance literature:

With copper(l) iodide; sodium L-ascorbate; In dimethyl sulfoxide; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1007/s11172-010-0100-9

Reference yield: 83.0%

(E)-3-(2-azidophenyl)acrylic acid (40515-78-4) + propynoic acid ethyl ester (623-47-2) → (E)-ethyl 1-(2-(2-bromovinyl)phenyl)-1H-1,2,3-triazole-4-carboxylate (1259940-08-3)

Guidance literature:

With N-Bromosuccinimide; copper(l) iodide; lithium acetate; sodium L-ascorbate; In water; acetonitrile; at 80 ℃; for 8h; optical yield given as %de; stereoselective reaction; Inert atmosphere;

DOI:10.1080/00397911.2010.481746

Reference yield:

2-nitrocinnamic acid (612-41-9) → (E)-ethyl 1-(2-(2-bromovinyl)phenyl)-1H-1,2,3-triazole-4-carboxylate (1259940-08-3)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; zinc / water / 0.5 h / 20 °C

2: sodium nitrite / water / 0.17 h / 0 °C

3: N-Bromosuccinimide; copper(l) iodide; lithium acetate; sodium L-ascorbate / water; acetonitrile / 8 h / 80 °C / Inert atmosphere

With N-Bromosuccinimide; copper(l) iodide; lithium acetate; acetic acid; sodium L-ascorbate; zinc; sodium nitrite; In water; acetonitrile;

DOI:10.1080/00397911.2010.481746

upstream raw materials:

(E)-3-(2-aminophenyl)-2-propenoic acid

(E)-3-(2-azidophenyl)acrylic acid

propynoic acid ethyl ester

2-nitrocinnamic acid