2-chloro-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-3-fluoroisonicotinamide

Base Information

• Chemical Name: 2-chloro-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-3-fluoroisonicotinamide
• CAS No.: 1269421-86-4
• Molecular Formula: C₂₃H₂₁Cl₂F₂N₃O₄S
• Molecular Weight: 544.406
• Mol file: 1269421-86-4.mol

Synonyms:2-chloro-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-3-fluoroisonicotinamide

Chemical Property of 2-chloro-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-3-fluoroisonicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-3-fluoroisonicotinamide

There total 4 articles about 2-chloro-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-3-fluoroisonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-3-fluoropyridine-4-carbonyl chloride (1225047-26-6) + N-(3-amino-2-chloro-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide (1269421-49-9) → 2-chloro-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-3-fluoroisonicotinamide (1269421-86-4)

Guidance literature:

In chloroform; at 20 ℃;

Reference yield:

p-methoxybenzyl chloride (824-94-2) → 2-chloro-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-3-fluoroisonicotinamide (1269421-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3.75 h / 20 - 40 °C / Cooling with ice

1.2: 14.08 h / 0 - 20 °C

2.1: chloroform / 20 °C

With sodium hydride; In chloroform; N,N-dimethyl-formamide; mineral oil;

Reference yield:

2-chloro-3-fluoro-pyridine-4-carboxylic acid (628691-93-0) → 2-chloro-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-3-fluoroisonicotinamide (1269421-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 2 h / 80 °C

2: chloroform / 20 °C

With thionyl chloride; In chloroform;

upstream raw materials:

p-methoxybenzyl chloride

2-chloro-3-fluoro-pyridine-4-carboxylic acid

2-chloro-3-fluoropyridine-4-carbonyl chloride

N-(3-amino-2-chloro-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide

Downstream raw materials:

N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-2-cyano-3-fluoroisonicotinamide

4-amino-N-(2-chloro-6-fluoro-3-(propylsulfonamido)phenyl)-pyrido[3,2-d]pyrimidine-8-carboxamide

4-amino-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)pyrido[3,2-d]pyrimidine-8-carboxamide