acide (benzyloxycarbonyl)-3-hydroxy-2-methoxy-4-methyl-6-benzoique

Base Information

• Chemical Name: acide (benzyloxycarbonyl)-3-hydroxy-2-methoxy-4-methyl-6-benzoique
• CAS No.: 57439-21-1
• Molecular Formula: C₁₇H₁₆O₆
• Molecular Weight: 316.31
• Mol file: 57439-21-1.mol

Synonyms:acide (benzyloxycarbonyl)-3-hydroxy-2-methoxy-4-methyl-6-benzoique

Chemical Property of acide (benzyloxycarbonyl)-3-hydroxy-2-methoxy-4-methyl-6-benzoique

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of acide (benzyloxycarbonyl)-3-hydroxy-2-methoxy-4-methyl-6-benzoique

There total 10 articles about acide (benzyloxycarbonyl)-3-hydroxy-2-methoxy-4-methyl-6-benzoique which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

formyl-3-hydroxy-2-methoxy-6-methyl-4-benzoate de benzyle (57439-18-6) → acide (benzyloxycarbonyl)-3-hydroxy-2-methoxy-4-methyl-6-benzoique (57439-21-1)

Guidance literature:

With sodium chlorite; aminosulfonic acid; In 1,4-dioxane; water; for 48h; Ambient temperature;

DOI:10.1002/hlca.19880710424

Reference yield:

2-hydroxy-4-methoxy-6-methyl-benzoic acid methyl ester (520-43-4) → acide (benzyloxycarbonyl)-3-hydroxy-2-methoxy-4-methyl-6-benzoique (57439-21-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 73 percent / TiCl₄ / CH₂Cl₂ / 5.5 h / Ambient temperature

2: 94 percent / 15percent KOH / 2 h / Heating

3: 86 percent / 2,2'-bipyridine, CuO₂ / bis-(2-methoxy-ethyl) ether / 5 h / Heating

4: 35 percent / NaClO₂, sulfamic acid / H₂O; dioxane / 48 h / Ambient temperature

5: 62 percent / NaHCO₃ / dimethylformamide / 20 h / Ambient temperature

6: 62 percent / TiCl₄ / CHCl₃; hexane / 5.5 h / Ambient temperature

7: 80 percent / NaClO₂, sulfamic acid / H₂O; dioxane / 48 h / Ambient temperature

With [2,2]bipyridinyl; potassium hydroxide; sodium chlorite; aminosulfonic acid; titanium tetrachloride; sodium hydrogencarbonate; In 1,4-dioxane; hexane; dichloromethane; chloroform; diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19880710424

Reference yield:

hydroxy-2-methoxy-6-methyl-4-benzaldehyde (39503-23-6) → acide (benzyloxycarbonyl)-3-hydroxy-2-methoxy-4-methyl-6-benzoique (57439-21-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 35 percent / NaClO₂, sulfamic acid / H₂O; dioxane / 48 h / Ambient temperature

2: 62 percent / NaHCO₃ / dimethylformamide / 20 h / Ambient temperature

3: 62 percent / TiCl₄ / CHCl₃; hexane / 5.5 h / Ambient temperature

4: 80 percent / NaClO₂, sulfamic acid / H₂O; dioxane / 48 h / Ambient temperature

With sodium chlorite; aminosulfonic acid; titanium tetrachloride; sodium hydrogencarbonate; In 1,4-dioxane; hexane; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19880710424

upstream raw materials:

formyl-3-hydroxy-2-methoxy-6-methyl-4-benzoate de benzyle

2-hydroxy-4-methoxy-6-methyl-benzoic acid methyl ester

hydroxy-2-methoxy-6-methyl-4-benzaldehyde

acide formyl-3-hydroxy-2-methoxy-4-methyl-6-benzoique

Downstream raw materials:

(benzyloxycarbonyl)-3-hydroxy-2-methoxy-4-methyl-6-benzoate de formyl-3-dihydroxy-2,4-methyl-6-phenyl

acide decarboxythamnolique

benzyl 2',4'-di-O-benzyldecarboxyhypothamnolate

Refernces