520-43-4Relevant academic research and scientific papers
SELECTIVE INHIBITION OF THE BIOSYNTHESIS OF PENICILLIC ACID
Lari, Jalil,Thomas, Robert
, p. 3305 - 3308 (1980)
5-Chloroorsellinic acid inhibits the formation of penicillic acid by Penicillium cyclopium at sublethal concentrations.
STRUCTURES OF MELLEOLIDES B-D, THREE ANTIBACTERIAL SESQUITERPENOIDS FROM ARMILLARIA MELLEA
Arnone, Alberto,Cardillo, Rosanna,Nasini, Gianluca
, p. 471 - 474 (1986)
Key Word Index-Armillaria mellea; Basidiomycete; secondary metabolites; protoilludane derivatives; structural determination.The structures of melleolides B-D, three new protoilludene sesquiterpenoid O-methylorsellinates isolated from a culture of Armillaria mellea, have been elucidated on the basis of chemical and spectral data.
Photolytic Studies on the Generation and Trapping of 6-Oxomethylidenecyclohexa-2,4-diene-1-one Derivatives with Various Nucleophiles
Mies, Thomas,White, Andrew J. P.,Parsons, Philip J.,Barrett, Anthony G. M.
, (2021/11/17)
α-Oxoketenes and cyclohexadiene α-oxoketenes are reactive intermediates, particularly the latter due to their high re-aromatization potential. In this communication, we report photolytic studies on the generation of such species from 4-OMe and 4-OMOM protected resorcylate dioxinones and their trapping to give resorcylate esters and amides as well as the formation of adducts with enol-ethers as trapping reagents.
Cajan element structure and methods in the application of preparing antibacterial drug
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Paragraph 0140-0142, (2018/02/04)
The invention belongs to the field of medicines and discloses a longistyline analogue and an application thereof in preparation of an antibacterial drug. The longistyline analogue has a structure as shown in the formula I described in the specification, w
Synthesis of 3-arylisocoumarins by using acyl anion chemistry and synthesis of thunberginol A and cajanolactone A
Sudarshan, Kasireddy,Manna, Manash Kumar,Aidhen, Indrapal Singh
, p. 1797 - 1803 (2015/05/27)
A new strategy for the synthesis of 3-arylisocoumarins and 8-hydroxy-3-arylisocoumarins was investigated by using acyl anion chemistry for the initial C-C bond formation. The obtained keto esters and keto lactones as intermediates underwent based-promoted intramolecular cyclization to afford 3-arylisocoumarins in good yields. The developed methodology was applied for the synthesis of the important natural products thunberginol A and cajanolactone A.
Novel cajaninstilbene acid derivatives as antibacterial agents
Geng, Zhi-Zhong,Zhang, Jian-Jun,Lin, Jing,Huang, Mei-Yan,An, Lin-Kun,Zhang, Hong-Bin,Sun, Ping-Hua,Ye, Wen-Cai,Chen, Wei-Min
, p. 235 - 245 (2015/06/25)
Discovery of novel antibacterial agents with new structural scaffolds that combat drug-resistant pathogens is an urgent task. Cajaninstilbene acid, which is isolated from pigeonpea leaves, has shown antibacterial activity. In this study, a series of cajaninstilbene acid derivatives were designed and synthesized. The antibacterial activities of these compounds against gram-negative and gram-positive bacteria, as well as nine strains of methicillin-resistant staphylococcus aureus (MRSA) bacteria are evaluated, and the related structure-activity relationships are discussed. Assays suggest that some of the synthetic cajaninstilbene acid derivatives exhibit potent antibacterial activity against gram-positive bacterial strains and MRSA. Among these compounds, 5b, 5c, 5j and 5k show better antibacterial activity than the positive control compounds. The results of MTT assays illustrate the low cytotoxicity of the active compounds.
First stereoselective total synthesis of Neocosmosin A: A facile approach
Dachavaram, Soma Shekar,Kalyankar, Kondbarao Balasaheb,Das, Saibal
supporting information, p. 5629 - 5631 (2014/12/11)
First stereoselective concise synthesis of Neocosmosin A, with in vitro binding affinity for human opioid and cannabinoid receptors, has been reported using readily available starting materials such as methylacetoacetate, cyclohexanone, and homoallyl alco
Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead
Du,Matsushima,Spyvee,Goto,Shirota,Gusovsky,Chiba,Kotake,Yoneda,Eguchi,DiPietro,Harmange,Gilbert,Li,Davis,Jiang,Zhang,Pelletier,Wong,Sakurai,Yang,Ito-Igarashi,Kimura,Kuboi,Mizui,Tanaka,Ikemori-Kawada,Kawakami,Inoue,Kawai,Kishi,Wang
supporting information; scheme or table, p. 6196 - 6199 (2010/06/19)
With bioactivity-guided phenotype screenings, a potent anti-inflammatory compound f152A1 has been isolated, characterized and identified as the known natural product LL-Z1640-2. Metabolic instability precluded its use for the study on animal disease model
Regioselective synthesis of polyketide-type phenols by formal [3+3]-cyclocondensations of 1,3-bis(silyloxy)-1,3-butadienes with 3-oxoorthoesters
Lubbe, Mathias,Gütlein, J?rg-Peter,Reinke, Helmut,Langer, Peter
experimental part, p. 2671 - 2673 (2009/04/11)
A variety of 4-methoxysalicylates and related polyketide-type phenols are regioselectively prepared by the first formal [3+3]-cyclocondensations of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with 3-oxoorthoesters.
Regiospecific synthesis of 3-(2,6-dihydroxyphenyl)phthalides: application to the synthesis of isopestacin and cryphonectric acid
Mal, Dipakranjan,Pahari, Pallab,De, Saroj Ranjan
, p. 11781 - 11792 (2008/03/13)
DBU catalyzed condensation of phthalaldehydic acids and 1,3-diketones has been developed to be a general method for the synthesis of 3-substituted phthalides. This method, in combination with mercuric acetate mediated oxidative aromatization has been util
