1-(6-(Hydroxymethyl)pyridin-2-yl)ethanone

Base Information

Chemical Name:1-(6-(Hydroxymethyl)pyridin-2-yl)ethanone
CAS No.:135450-43-0
Molecular Formula:C₈H₉NO₂
Molecular Weight:151.165
Hs Code.:2933399090
DSSTox Substance ID:DTXSID70438114
Nikkaji Number:J2.536.169E
Wikidata:Q82253750
Mol file:135450-43-0.mol

Synonyms:135450-43-0;1-(6-(Hydroxymethyl)pyridin-2-yl)ethanone;1-[6-(hydroxymethyl)pyridin-2-yl]ethanone;Ethanone, 1-[6-(hydroxymethyl)-2-pyridinyl]- (9CI);1-(6-HYDROXYMETHYL-PYRIDIN-2-YL)-ETHANONE;1-[6-(HYDROXYMETHYL)PYRIDIN-2-YL]ETHAN-1-ONE;1-(6-(hydroxymethyl)pyridin-2-yl)ethan-1-one;6-Acetylpyridine-2-methanol;SCHEMBL1054149;2-acetyl-6-hydroxymethylpyridine;DTXSID70438114;HQJHOZUEJWJPKX-UHFFFAOYSA-N;2-Acetyl-6-(hydroxymethyl)pyridine;MFCD09029472;AKOS006288355;AB49267;1-[6-(hydroxymethyl)-2-pyridinyl]Ethanone;FT-0766724;J-006700

Suppliers and Price of 1-(6-(Hydroxymethyl)pyridin-2-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynChem
1-(6-HYDROXYMETHYL-PYRIDIN-2-YL)-ETHANONE 95+%
1 g
$ 750.00

Crysdot
1-(6-(Hydroxymethyl)pyridin-2-yl)ethanone 95+%
1g
$ 672.00

Chemenu
1-(6-(hydroxymethyl)pyridin-2-yl)ethan-1-one 95%
1g
$ 635.00

American Custom Chemicals Corporation
1-(6-HYDROXYMETHYL-PYRIDIN-2-YL)-ETHANONE 95.00%
100MG
$ 970.20

Alichem
1-(6-(Hydroxymethyl)pyridin-2-yl)ethanone
1g
$ 552.47

Total 8 raw suppliers

Chemical Property of 1-(6-(Hydroxymethyl)pyridin-2-yl)ethanone

Chemical Property:

Boiling Point:295.4 °C at 760 mmHg
PKA:13.05±0.10(Predicted)
Flash Point:132.5 °C
PSA：50.19000
Density:1.18 g/cm³
LogP:0.77650
XLogP3:0
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:151.063328530
Heavy Atom Count:11
Complexity:147

Purity/Quality:

98%Min ^*data from raw suppliers

1-(6-HYDROXYMETHYL-PYRIDIN-2-YL)-ETHANONE 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1=CC=CC(=N1)CO

Technology Process of 1-(6-(Hydroxymethyl)pyridin-2-yl)ethanone

There total 10 articles about 1-(6-(Hydroxymethyl)pyridin-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 162084-86-8
1-[6-(tert-butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-ethanone

: 135450-43-0
1-(6-(hydroxymethyl)pyridin-2-yl)ethan-1-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.666667h;

Reference yield: 69.0%

: 39977-44-1
methyl 6-(hydroxymethyl)pyridine-2-carboxylate

: 75-16-1
methylmagnesium bromide

: 933791-33-4
2-hydroxymethyl-6-(1-hydroxy-1-methylethyl)pyridine

: 135450-43-0
1-(6-(hydroxymethyl)pyridin-2-yl)ethan-1-one

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 3.5h; Inert atmosphere;
DOI:10.1021/acs.oprd.0c00124

Reference yield: 62.0%

: 110144-24-6
Methyl 2-acetylpyridine-6-carboxlyate

: 135450-43-0
1-(6-(hydroxymethyl)pyridin-2-yl)ethan-1-one

Guidance literature:: Methyl 2-acetylpyridine-6-carboxlyate; With trimethylsilyl trifluoromethanesulfonate; triethylphosphine; In dichloromethane; toluene; at 20 ℃; for 1h;

With diisobutylaluminium hydride; In hexane; dichloromethane; at 0 ℃; regioselective reaction;
DOI:10.1248/cpb.c13-00666