N,N-dimethyl-2-(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetamide

Base Information

Chemical Name:N,N-dimethyl-2-(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetamide
CAS No.:1273387-05-5
Molecular Formula:C₂₅H₂₆N₆O₃S₂
Molecular Weight:522.652
Hs Code.:

Synonyms:N,N-dimethyl-2-(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetamide

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Chemical Property of N,N-dimethyl-2-(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetamide

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Technology Process of N,N-dimethyl-2-(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetamide

There total 9 articles about N,N-dimethyl-2-(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1187450-51-6
(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)-acetic acid

: 124-40-3
dimethyl amine

: 1273387-05-5
N,N-dimethyl-2-(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetamide

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; at 20 ℃; for 15h;

Reference yield:

: 203321-86-2
6-tert-butoxycarbonylamino-pyridine-2-carboxylic acid ethyl ester

: 1273387-05-5
N,N-dimethyl-2-(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.33 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 1.17 h / 20 °C / Cooling with ice

2.1: ethanol; calcium chloride; sodium tetrahydroborate / Tetraethylene glycol dimethyl ether / 35 °C / Cooling with ice

2.2: 1.17 h / 29 °C / Cooling with ice

3.1: tributylphosphine; diamide / tetrahydrofuran / 12 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 50 h / 20 °C

5.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / tetrahydrofuran / 15 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; ethanol; tributylphosphine; diamide; sodium hydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; calcium chloride; In tetrahydrofuran; 1,4-dioxane; Tetraethylene glycol dimethyl ether; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1187451-27-9
2-{4-[bis(tert-butoxycarbonyl)aminomethyl]phenyl}thiazole

: 1273387-05-5
N,N-dimethyl-2-(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: triethylamine / dichloromethane / 3 h / 20 °C

3: tributylphosphine; diamide / tetrahydrofuran / 12 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 50 h / 20 °C

5: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / tetrahydrofuran / 15 h / 20 °C

With hydrogenchloride; tributylphosphine; diamide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;