Technology Process of 1-({4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]phenyl}methyl)-2-pyrrolidinone
There total 4 articles about 1-({4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]phenyl}methyl)-2-pyrrolidinone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
copper(l) iodide; dimethylaminoacetic acid;
In
dimethyl sulfoxide;
at 190 ℃;
for 0.5h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -70 °C / Inert atmosphere
1.2: -70 - 20 °C / Inert atmosphere
2.1: hydrazine hydrate / ethanol / 9 h / 60 - 70 °C / Inert atmosphere
3.1: copper(l) iodide; dimethylaminoacetic acid; potassium carbonate / dimethyl sulfoxide / 0.5 h / 190 °C / Microwave irradiation
With
copper(l) iodide; dimethylaminoacetic acid; potassium carbonate; hydrazine hydrate; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm100679e
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere; Cooling
1.2: 20 °C / Inert atmosphere
2.1: copper(l) iodide; dimethylaminoacetic acid; potassium carbonate / dimethyl sulfoxide / 0.5 h / 190 °C / Microwave irradiation
With
copper(l) iodide; dimethylaminoacetic acid; sodium hydride; potassium carbonate;
In
dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm100679e