(S)-1,1,1,3,3,3-hexafluoropropan-2-yl 3-(4-bromophenyl)-3-(phenylthio)propanoate

Base Information

Chemical Name:(S)-1,1,1,3,3,3-hexafluoropropan-2-yl 3-(4-bromophenyl)-3-(phenylthio)propanoate
CAS No.:1443455-83-1
Molecular Formula:C₁₈H₁₃BrF₆O₂S
Molecular Weight:487.26
Hs Code.:

Synonyms:(S)-1,1,1,3,3,3-hexafluoropropan-2-yl 3-(4-bromophenyl)-3-(phenylthio)propanoate

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Chemical Property of (S)-1,1,1,3,3,3-hexafluoropropan-2-yl 3-(4-bromophenyl)-3-(phenylthio)propanoate

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Technology Process of (S)-1,1,1,3,3,3-hexafluoropropan-2-yl 3-(4-bromophenyl)-3-(phenylthio)propanoate

There total 2 articles about (S)-1,1,1,3,3,3-hexafluoropropan-2-yl 3-(4-bromophenyl)-3-(phenylthio)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1443456-02-7
C₁₂H₇BrF₆O₂

: 108-98-5
thiophenol

: 1443455-83-1
(S)-1,1,1,3,3,3-hexafluoropropan-2-yl 3-(4-bromophenyl)-3-(phenylthio)propanoate

Guidance literature:: In toluene; at 0 ℃;
DOI:10.1039/d0gc02855j

Reference yield:

: 1200-07-3
3-(4-bromophenyl)acrylic acid

: 1443455-83-1
(S)-1,1,1,3,3,3-hexafluoropropan-2-yl 3-(4-bromophenyl)-3-(phenylthio)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 12 h / 20 °C

2: N-((1R,2R)-2-(3-((1R,2R)-2-(dimethylamino)cyclohexyl)thioureido)-1,2-diphenylethyl)-3,5-bis(trifluoromethyl)benzenesulfonamide / toluene / 0 °C / Inert atmosphere; Schlenk technique

With dmap; N-((1R,2R)-2-(3-((1R,2R)-2-(dimethylamino)cyclohexyl)thioureido)-1,2-diphenylethyl)-3,5-bis(trifluoromethyl)benzenesulfonamide; dicyclohexyl-carbodiimide; In dichloromethane; toluene; 2: |Michael Addition;
DOI:10.1021/ol4015305