3-Chloro-2-hydrazinopyridine

Base Information

• Chemical Name: 3-Chloro-2-hydrazinopyridine
• CAS No.: 22841-92-5
• Molecular Formula: C5H6ClN3
• Molecular Weight: 143.576
• Hs Code.: 2933399090
• European Community (EC) Number: 474-260-2,690-673-2
• DSSTox Substance ID: DTXSID20945540
• Nikkaji Number: J2.135.632H
• Wikidata: Q72451699
• Mol file: 22841-92-5.mol

Synonyms:3-Chloro-2-hydrazinopyridine;22841-92-5;3-Chloro-2-hydrazinylpyridine;(3-CHLORO-PYRIDIN-2-YL)-HYDRAZINE;(3-Chloropyridin-2-yl)hydrazine;1-(3-chloropyridin-2-yl)hydrazine;2-hydrazino-3-chloropyridine;2(1H)-Pyridinone, 3-chloro-, hydrazone;MFCD01936479;3-chloro-2(1H)-pyridinone hydrazone;Pyridine,3-chloro-2-hydrazinyl-;3-Chloro-2-hydrazylpyridine;2-Hydrazinyl-3-chloropyridine;3-chloropyridin-2-ylhydrazine;SCHEMBL385136;C7H17N2O.BF4;3-Chloro-2-hydrazinopyridine #;DTXSID20945540;1-(3-Chloro-2-pyridyl)hydrazine;3-chloro-2-pyridin-2-ylhydrazine;BCP15445;C7-H17-N2-O.B-F4;AKOS000133653;AKOS028109413;CS-W002868;SB75557;22960-83-4;3-chloro-2-hydrazinopyridine, AldrichCPR;SY011483;A4860;AM20070282;FT-0657238;EN300-44833;2-Ethoxy-1-methyl-t-butyldiazenium fluoroborate;8B-018;J-503131;Diazenium, 1-tert-butyl-2-ethoxy-1-methyl-, tetrafluoroborate;Diazenium, 1-tert-butyl-2-ethoxy-1-methyl-, tetrafluoroborate(1-);Diazenium, 1-(1,1-dimethylethyl)-2-ethoxy-1-methyl-, tetrafluoroborate(1-)

Chemical Property of 3-Chloro-2-hydrazinopyridine

Chemical Property:

• Vapor Pressure: 0.00474mmHg at 25°C
• Melting Point: 165-167 °C
• Refractive Index: 1.668
• Boiling Point: 276.7 °C at 760 mmHg
• PKA: 8.65±0.70(Predicted)
• Flash Point: 121.1 °C
• PSA: 50.94000
• Density: 1.418 g/cm³
• LogP: 1.79390
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 143.0250249
• Heavy Atom Count: 9
• Complexity: 88.3

Purity/Quality:

99.0%, ^*data from raw suppliers

3-Chloro-2-hydrazinopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)NN)Cl

Technology Process of 3-Chloro-2-hydrazinopyridine

There total 9 articles about 3-Chloro-2-hydrazinopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.12%

2,3-dichloro-pyridine (2402-77-9) → (3-chloro-2-pyridyl)hydrazine (22841-92-5)

Guidance literature:

With N-Methyldiethanolamine; hydrazine hydrate; at 102 - 105 ℃; for 8h; under 2250.23 - 3000.3 Torr; Inert atmosphere; Autoclave; Large scale;

Reference yield: 96.93%

3-chloro-2-pyridinesulfonic acid → (3-chloro-2-pyridyl)hydrazine (22841-92-5)

Guidance literature:

With hydrazine monohydrate; monoethanolamine; In 5,5-dimethyl-1,3-cyclohexadiene; at 150 ℃; for 15h; Temperature;

Reference yield: 90.2%

2-hydrazino-3,6-dichloropyridine → (3-chloro-2-pyridyl)hydrazine (22841-92-5)

Guidance literature:

With hydrogen; In methanol; for 5h; under 6000.6 - 10501.1 Torr; Reflux;

upstream raw materials:

3-chloro-2-nitropyridine

2,3-dichloro-pyridine

hydrazine hydrate

pyridin-3-ylamine

Downstream raw materials:

8-chlorotrazolo<1,5-a>pyridine

2-(3-chloro-pyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylic acid ethyl ester

Refernces

• 1、 Shi, Jian-Jun,Ren, Gui-Hua,Wu, Ning-Jie,Weng, Jian-Quan,Xu, Tian-Ming,Liu, Xing-Hai,Tan, Cheng-Xia. "Design, synthesis and insecticidal activities of novel anthranilic diamides containing polyfluoroalkyl pyrazole moiety". . p. 1727 - 1730. Retrieved 2017.
• 2、 Huo, Jingqian,Zhao, Bin,Zhang, Zhe,Xing, Jihong,Zhang, Jinlin,Dong, Jingao,Fan, Zhijin. "Structure-based discovery and synthesis of potential transketolase inhibitors". . . Retrieved 2018.
• 3、 Ke, Wei,Sun, Na-Bo,Wu, Hong-Ke. "Microwave-assistant synthesis, crystal structure and fungicidal activity of 3-Chloro-2-hydrazinylpyridine". . p. 8708 - 8710. Retrieved 2013.
• 4、 Chen, Rui-Jia,Cheng, Jia-Gao,Dong, Le-Feng,Feng, Ting-Ting,Gu, Yu-Cheng,Li, Zhong,Shao, Xu-Sheng,Wang, Gang-Ao,Wang, Jun-Jie,Xu, Xiao-Yong,Xu, Zhi-Ping,Zhou, Cong. "Diamides conformationally restricted with central amino acid: Design, synthesis, and biological activities". . . Retrieved 2022/02/03.
• 5、 -. "2-hydrazino-3-chloropyridine improvement process". Paragraph 0023; 0030-0034. . Retrieved 2021/04/26.